Findings

What do systematic reviews say?

203 questions · 206 findings · 21 reviews

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No studies found 51 · 24.8%GRADE not reported 11 · 5.3%Very low 59 · 28.6%Low 57 · 27.7%Moderate 19 · 9.2%High 9 · 4.4%

Intervention not reported

Serious adverse events · people with cancer pain

1 finding from 1 review

Oral paracetamol (acetaminophen) for cancer pain 2017 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 93 participants
Very low

Paracetamol 1000 mg vs placebo

Pain‐free at 2 hours · adults with episodic tension‐type headache

1 finding from 1 review

Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
High

Paracetamol 500 mg to 650 mg vs placebo

Pain‐free at 1 hour · adults with episodic tension‐type headache

The review found no eligible studies for this question.

2 findings from 1 review

Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Paracetamol 500 mg to 650 mg vs placebo

Use of rescue medication · adults with episodic tension‐type headache

1 finding from 1 review

Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Paracetamol 500 mg to 650 mg vs placebo

Pain‐free or mild pain at 2 hours · adults with episodic tension‐type headache

1 finding from 1 review

Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Paracetamol 500 mg to 650 mg vs placebo

Any adverse event · adults with episodic tension‐type headache

1 finding from 1 review

Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Paracetamol 500 mg to 650 mg vs placebo

Serious adverse events · adults with episodic tension‐type headache

1 finding from 1 review

Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Paracetamol 1000 mg vs placebo

Pain‐free at 1 hour · adults with episodic tension‐type headache

2 findings from 1 review

Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate
Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

Paracetamol 1000 mg vs placebo

Use of rescue medication · adults with episodic tension‐type headache

1 finding from 1 review

Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

Paracetamol 1000 mg vs placebo

Pain‐free or mild pain at 2 hours · adults with episodic tension‐type headache

1 finding from 1 review

Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
High

Paracetamol 1000 mg vs placebo

Any adverse event · adults with episodic tension‐type headache

1 finding from 1 review

Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
High

Paracetamol 1000 mg vs placebo

Serious adverse events · adults with episodic tension‐type headache

1 finding from 1 review

Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

Paracetamol 500 mg to 650 mg vs placebo

Pain‐free at 2 hours · adults with episodic tension‐type headache

The review found no eligible studies for this question.

1 finding from 1 review

Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Paracetamol alone, paracetamol plus codeine, or paracetamol plus dihydrocodeine vs placebo

Moderate benefit: At least 30% reduction in pain, or PGIC much or very much improved · adults with chronic neuropathic pain

1 finding from 1 review

Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Paracetamol alone, paracetamol plus codeine, or paracetamol plus dihydrocodeine vs placebo

Substantial benefit: At least 50% reduction in pain, or PGIC much improved · adults with chronic neuropathic pain

1 finding from 1 review

Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Paracetamol alone, paracetamol plus codeine, or paracetamol plus dihydrocodeine vs placebo

Lack of efficacy withdrawal · adults with chronic neuropathic pain

1 finding from 1 review

Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Paracetamol alone, paracetamol plus codeine, or paracetamol plus dihydrocodeine vs placebo

Withdrawals due to adverse events · adults with chronic neuropathic pain

1 finding from 1 review

Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Paracetamol alone, paracetamol plus codeine, or paracetamol plus dihydrocodeine vs placebo

Serious adverse events · adults with chronic neuropathic pain

1 finding from 1 review

Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Paracetamol alone, paracetamol plus codeine, or paracetamol plus dihydrocodeine vs placebo

Deaths · adults with chronic neuropathic pain

1 finding from 1 review

Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Intervention not reported

At least 50% reduction in pain or equivalent · Adults with cancer pain

1 finding from 1 review

Codeine, alone and with paracetamol (acetaminophen), for cancer pain 2014 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 69 participants
Very low