Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,973 questions · 3,072 findings · 410 reviews · Headline outcomes only

No studies found 559 · 18.2%GRADE not reported 143 · 4.7%Very low 654 · 21.3%Low 833 · 27.1%Moderate 683 · 22.2%High 200 · 6.5%

Summary of Findings Table ‐ Ibuprofen 300 mg vs paracetamol

Number of participants reporting an adverse event · health problem or population

It is very uncertain whether summary of Findings Table ‐ Ibuprofen 300 mg changes number of participants reporting or experiencing any adverse event compared with active comparator (acetaminophen) (very low certainty).

1 finding from 1 review

Summary of Findings Table ‐ Ibuprofen 300 mg vs paracetamol

At least 50% reduction in pain · health problem or population

It is very uncertain whether summary of Findings Table ‐ Ibuprofen 300 mg changes number of participants with at least 50% pain relief at 4 hours compared with active comparator (acetaminophen) (very low certainty).

2 findings from 1 review

Intervention not reported

Change in anxiety · various, including general population, pregnant people, psychiatric populations (ADHD, alcohol use disorder, anxiety disorder, depression,…
1 finding from 1 review

Intervention not reported

Change in depression · various, including general population, pregnant people, psychiatric populations (ADHD, alcohol use disorder, anxiety disorder, depression,…
1 finding from 1 review

Intervention not reported

Mixed anxiety and depression · various, including general population, pregnant people, psychiatric populations (ADHD, alcohol use disorder, anxiety disorder, depression,…
1 finding from 1 review