Arrest or reversal of noncavitated approximal carious lesions · Children and adults with noncavitated carious lesions on approximal surfaces (primary and permanent teeth)
Resin infiltration + 5% NaF varnish may not differ from Sealant for arrest or reversal of approximal carious lesions (RR 1.91, 95% CI 0.48 to 7.52; very low certainty).
1 finding from 1 review
Prevalence and severity of oral and TMJ diseases/conditions (periodontal status and dental caries) · Children and adolescents with juvenile idiopathic arthritis (JIA)
Some studies suggested greater JIA disease activity/severity (and certain medications) was associated with worse periodontal and caries outcomes, but small samples meant no solid conclusion could be drawn (ungraded).
1 finding from 1 review
Dental maturation (tooth calcification) · Children and adolescents with juvenile idiopathic arthritis (JIA)
Evidence on dental maturation was divergent across two studies (one found more advanced maturation in JIA, one found no difference); no clear conclusion (ungraded).
1 finding from 1 review
Arrest or reversal of noncavitated occlusal carious lesions · Children and adults with noncavitated carious lesions on occlusal surfaces (primary and permanent teeth)
0.2% NaF mouthrinse + supervised toothbrushing was probably less effective than Sealant + 5% NaF varnish for arrest or reversal of occlusal carious lesions (RR 0.58, 95% CI 0.43 to 0.79; moderate certainty).
1 finding from 1 review
Pathological mobility · Children with carious vital pulp exposure in primary incisors
Pathological mobility was rare (one tooth in one of four trials) and was not pooled.
1 finding from 1 review
Arrest or reversal of noncavitated carious lesions on any coronal surface · Children and adults with noncavitated carious lesions on any coronal surface (primary and permanent teeth)
10% CPP-ACP paste may not differ from no treatment for arrest or reversal of any-coronal carious lesions (RR 1.03, 95% CI 0.9 to 1.18; low certainty).
1 finding from 1 review
Plaque · Medically healthy individuals (adults and children, 6-60 years)
0.12% chlorhexidine rinse reduced plaque relative to baseline; not GRADE-rated.
1 finding from 1 review
Pathological root resorption · Children with carious vital pulp exposure in primary incisors
No statistically significant difference in pathological root resorption between pulpotomy and pulpectomy (RR 1.5, 95% CI 0.56 to 4.04; ungraded).
1 finding from 1 review
RR 1.5 [0.56, 4.04]
2 studies
GRADE not reported
Average enamel surface roughness · Extracted human teeth with early/artificial enamel lesions (in vitro)
In vitro, CPP-ACP markedly reduced enamel surface roughness versus control (SMD -8.21, 95% CI -10.37 to -6.04; ungraded).
1 finding from 1 review
Plaque · Medically healthy individuals (adults and children, 6-60 years)
Salvadora persica rinse reduced plaque relative to its own baseline; not GRADE-rated.
1 finding from 1 review
Arrest or reversal of noncavitated occlusal carious lesions · Children and adults with noncavitated carious lesions on occlusal surfaces (primary and permanent teeth)
1.23% APF gel may not differ from 5% NaF varnish for arrest or reversal of occlusal carious lesions (RR 1.08, 95% CI 0.83 to 1.4; low certainty).
2 findings from 1 review
Streptococcus mutans count · Medically healthy individuals (adults and children, 6-60 years)
Placebo rinse did not significantly change Streptococcus mutans counts relative to baseline; not GRADE-rated.
1 finding from 1 review
Physiological stress indicators (heart rate, oxygen saturation) · Children (ages 6-12) receiving pit-and-fissure sealants
Heart rate and oxygen saturation did not differ significantly between laser-plus-acid and acid-etching (ungraded, single study).
1 finding from 1 review
Arrest or reversal of noncavitated occlusal carious lesions · Children and adults with noncavitated carious lesions on occlusal surfaces (primary and permanent teeth)
0.2% NaF mouthrinse + supervised toothbrushing may not differ from 5% NaF varnish for arrest or reversal of occlusal carious lesions (RR 0.99, 95% CI 0.84 to 1.15; low certainty).
1 finding from 1 review
Arrest or reversal of noncavitated and cavitated root carious lesions · Adults (including institutionalized/older adults) with noncavitated and cavitated carious lesions on root surfaces (permanent teeth)
5% NaF varnish may not differ from no treatment for arrest or reversal of root carious lesions (RR 2.96, 95% CI 0.27 to 32.26; very low certainty).
1 finding from 1 review
Intervention not reported
Dental caries prevalence · Children (<12 years) and adolescents (12-18 years) with type 1 diabetes
The pooled prevalence of dental caries among children and adolescents with type 1 diabetes was 67% (95% CI 0.56 to 0.77), with high heterogeneity (I2=83%); certainty not graded.
1 finding from 1 review
Arrest or reversal of noncavitated and cavitated root carious lesions · Adults (including institutionalized/older adults) with noncavitated and cavitated carious lesions on root surfaces (permanent teeth)
1% chlorhexidine + 1% thymol varnish may not differ from 5% NaF varnish for arrest or reversal of root carious lesions (RR 0.57, 95% CI 0.04 to 8.69; very low certainty).
1 finding from 1 review
DMFT/DMFS index (dental caries experience) · Children with dental caries
Oral-health promotion programs were associated with markedly lower odds of DMFT/S in children (OR 0.19, 95% CI 0.10 to 0.39; ungraded, very high heterogeneity I2=98.5%).
1 finding from 1 review
OR 0.19 [0.10, 0.39]
8 studies
GRADE not reported
Arrest or reversal of noncavitated approximal carious lesions · Children and adults with noncavitated carious lesions on approximal surfaces (primary and permanent teeth)
5% NaF varnish may not differ from no treatment for arrest or reversal of approximal carious lesions (RR 2.29, 95% CI 0.74 to 7.1; very low certainty).
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Immature (young) permanent teeth with open apex and vital pulp exposed to dental caries or trauma, in children aged 6-14 years
A single RCT found higher pulpotomy success with MTA than abscess remedy (100% vs 80%; statistically significant, P<0.05; not pooled; ungraded).
1 finding from 1 review
Single RCT (Eppa 2018, 3-arm; 20 MTA and 20 AR teeth): MTA 100% (20/20) vs abscess remedy 80% (16/20) clinical and radiographic success; the 4 abscess-remedy failures occurred at 3 months; difference statistically…
1 study · 40 participants
GRADE not reported