What do systematic reviews say?

Intervention not reported

• Pharmacological interventions for prevention and treatment of upper gastrointestinal bleeding in newborn infants 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 104 participants
  Very low

Primary (complete) wound closure vs delayed closure

It is very uncertain whether primary closure changes proportion of wounds which were infection free on day 7 compared with delayed closure (very low certainty).

• ​Primary closure versus delayed or no closure for traumatic wounds due to mammalian bite 2019 · Cochrane Headline outcomes only
  RR 0.98 [0.9, 1.07]
  1 study · 120 participants
  Very low

Robotic‐assisted laparoscopic vs open radical cystectomy

• Robotic versus open radical cystectomy for bladder cancer in adults 2019 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 541 participants
  Low

Omega‐3 fatty acids and antioxidants vs standard diet or placebo

• Immunonutrition for acute respiratory distress syndrome (ARDS) in adults 2019 · Cochrane Headline outcomes only
  no estimate extracted
  8 studies · 639 participants
  Very low

Omega‐3 fatty acids and antioxidants vs standard diet or placebo

• Immunonutrition for acute respiratory distress syndrome (ARDS) in adults 2019 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 581 participants
  Very low

Omega‐3 fatty acids and antioxidants vs standard diet or placebo

• Immunonutrition for acute respiratory distress syndrome (ARDS) in adults 2019 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 659 participants
  Very low

Fexofenadine 120 mg/d vs placebo (1‐week intervention)

• Oral H1 antihistamines as ‘add‐on’ therapy to topical treatment for eczema 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 400 participants
  Moderate

Zinc tape vs gauze soaked

• Interventions for ulceration and other skin changes caused by nerve damage in leprosy 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 90 participants
  Very low

Psychological therapies vs controls

• Psychological therapies for the prevention of migraine in adults 2019 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 681 participants
  Very low

Continuous local anaesthetic wound infusion vs placebo

• Continuous local anaesthetic wound infusion for postoperative pain after midline laparotomy for colorectal resection… 2019 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 511 participants
  High

Continuous local anaesthetic wound infusion vs placebo

• Continuous local anaesthetic wound infusion for postoperative pain after midline laparotomy for colorectal resection… 2019 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 407 participants
  Low

Continuous local anaesthetic wound infusion vs placebo

• Continuous local anaesthetic wound infusion for postoperative pain after midline laparotomy for colorectal resection… 2019 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 528 participants
  Moderate

Continuous local anaesthetic wound infusion vs placebo

• Continuous local anaesthetic wound infusion for postoperative pain after midline laparotomy for colorectal resection… 2019 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 197 participants
  Moderate

Continuous local anaesthetic wound infusion vs placebo

• Continuous local anaesthetic wound infusion for postoperative pain after midline laparotomy for colorectal resection… 2019 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 456 participants
  High

Early enteral nutrition vs delayed enteral nutrition

It is very uncertain whether early enteral nutrition changes mortality (measured at 30 days) compared with delayed enteral nutrition (very low certainty).

• Early enteral nutrition (within 48 hours) versus delayed enteral nutrition (after 48 hours) with or without… 2019 · Cochrane Headline outcomes only
  RR 1 [0.16, 6.38]
  1 study · 38 participants
  Very low

Early enteral nutrition with supplemental parenteral nutrition (SPN) vs delayed enteral nutrition with SPN

The review found no eligible studies for this question.

• Early enteral nutrition (within 48 hours) versus delayed enteral nutrition (after 48 hours) with or without… 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Early enteral nutrition with supplemental parenteral nutrition (SPN) vs delayed enteral nutrition with SPN

• Early enteral nutrition (within 48 hours) versus delayed enteral nutrition (after 48 hours) with or without… 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 27 participants
  Very low

Early enteral nutrition vs delayed enteral nutrition

• Early enteral nutrition (within 48 hours) versus delayed enteral nutrition (after 48 hours) with or without… 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 59 participants
  Very low

Early enteral nutrition vs delayed enteral nutrition

• Early enteral nutrition (within 48 hours) versus delayed enteral nutrition (after 48 hours) with or without… 2019 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 125 participants
  Very low

Rigid dressings vs soft dressings

• Rigid dressings versus soft dressings for transtibial amputations 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 56 participants
  Very low