Cochrane · systematic review · CD011785
Pharmacological interventions for prevention and treatment of upper gastrointestinal bleeding in newborn infants
Green, DS, Abdel‐Latif, ME, Jones, LJ, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 33.3%Low 3 · 50%Moderate 1 · 16.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Prevention of upper gastrointestinal bleeding in newborn infants
Population: newborn infants at risk of gastrointestinal bleeding
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality | RR 2.42 [0.7, 8.38] | 1 study · 53 participants | Very low Downgraded: imprecision |
Any upper gastrointestinal bleeding in infants at risk of upper gastrointestinal bleeding | RR 0.36 [0.22, 0.58] | 4 studies · 329 participants | Moderate |
Treatment of upper gastrointestinal bleeding in newborn infants
Population: infants with upper gastrointestinal bleeding
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality | RR 0.63 [0.26, 1.51] | 2 studies · 131 participants | Low Downgraded: imprecision |
Duration of upper gastrointestinal bleeding (days) | no estimate extracted | 2 studies · 104 participants | Very low Downgraded: imprecision, inconsistency |
Continued upper gastrointestinal bleeding | RR 0.36 [0.26, 0.49] | 6 studies · 451 participants | Low Downgraded: inconsistency |
Anaemia requiring blood transfusion | RR 0.6 [0.11, 3.19] | 1 study · 38 participants | Low Downgraded: inconsistency |