Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,454 questions · 3,562 findings · 816 reviews · Headline outcomes only

No studies found 538 · 15.1%GRADE not reported 239 · 6.7%Very low 933 · 26.2%Low 1,041 · 29.2%Moderate 612 · 17.2%High 199 · 5.6%

Standard ready‐to‐use therapeutic food (RUTF) provided at a dose that meets total daily nutritional requirements vs RUTF using an alternative formulation

Rate of weight gain (g/kg/day) · children aged 6 months‐5 years with SAM (and mixed HIV comorbidity), some of whom had been stabilised as inpatients pre‐trial
1 finding from 1 review

Standard ready‐to‐use therapeutic food (RUTF) provided at a dose that meets total daily nutritional requirements vs an alternative dietary approach

Rate of weight gain (g/kg/day) · children aged 6 months‐5 years with SAM (and mixed HIV comorbidity), some of whom had been stabilised as inpatients pre‐trial
1 finding from 1 review

Standard ready‐to‐use therapeutic food (RUTF) provided at a dose that meets total daily nutritional requirements vs as a supplement to the usual diet

Rate of weight gain (g/kg/day) · children aged 6 months‐5 years with SAM (1 study included HIV‐uninfected children; 1 study included HIV‐infected children), all of whom…
1 finding from 1 review

Integrated CBT vs Twelve Step Facilitation

Percent of days abstinent · co‐occurring depression and substance use disorders
2 findings from 1 review

Corticosteroids vs no corticosteroid use

All‐cause mortality Up to 28 days following admission · individuals with influenza

It is very uncertain whether corticosteroid therapy changes number of deaths at 30 days following admission (30‐day mortality)a compared with no corticosteroid therapy (very low certainty).

1 finding from 1 review