Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,320 questions · 4,561 findings · 388 reviews

No studies found 1,138 · 25%GRADE not reported 886 · 19.4%Very low 1,014 · 22.2%Low 849 · 18.6%Moderate 543 · 11.9%High 131 · 2.9%

Autopolymerised sealant vs Light polymerised sealant

Development of >=1 new carious lesion (caries incidence) · Children with sound primary molars, aged 2-4 years (municipal dental clinics or hospital paediatric clinics, Denmark)

It is very uncertain whether autopolymerised sealant changes development of >=1 new carious lesion (caries incidence) compared with light polymerised sealant (very low certainty).

1 finding from 1 review

CBT vs inactive control (usual care care, attention control, waitlist)

Mental distress · People aged 12 years and over with painful TMD lasting 3 months or longer

Cognitive behavioural therapy (CBT) showed no clear difference in psychological distress at follow-up compared with usual care, waiting list or no treatment (control) (low certainty).

2 findings from 1 review

Single-visit root canal treatment vs Multiple-visit root canal treatment (two or more visits)

Pain at 12 months or more (long-term postobturation pain) · People aged 10 years or above requiring root canal treatment; permanent teeth with completely formed apex and without internal resorption
1 finding from 1 review

Single-visit root canal treatment vs Multiple-visit root canal treatment (two or more visits)

Sinus or fistula formation at last · People aged 10 years or above requiring root canal treatment; permanent teeth with completely formed apex and without internal resorption

It is very uncertain whether single-visit root canal treatment changes sinus tract or fistula formation compared with multiple-visit root canal treatment (two or more visits) (very low certainty).

1 finding from 1 review

Periodontal treatment (subgingival instrumentation, with or without antimicrobials/surgery) vs usual care or no treatment

Diabetic complications · People with diabetes mellitus (type 1 or type 2, mostly type 2) and periodontitis, at least 16 years of age

The review found no eligible studies for this question.

1 finding from 1 review

Single-visit root canal treatment vs Multiple-visit root canal treatment (two or more visits)

Postoperative pain intensity in the immediate postobturation period (up to 72 hours), continuous (VAS) · People aged 10 years or above requiring root canal treatment; permanent teeth with completely formed apex and without internal resorption

Single-visit root canal treatment showed no clear difference in postoperative pain intensity in the immediate postobturation period… compared with multiple-visit root canal treatment (two or more visits) (low certainty).

1 finding from 1 review

Periodontal treatment (subgingival instrumentation, with or without antimicrobials/surgery) vs usual care or no treatment

Adverse effects of treatment · People with diabetes mellitus (type 1 or type 2, mostly type 2) and periodontitis, at least 16 years of age
1 finding from 1 review

Traditional screening (referral card given if the inspecting dentist judges the child needs to see a dentist) vs No screening

Dental caries prevalence · School children (aged 4 to 15 years), primary and secondary schools in the UK and India
1 finding from 1 review
  • Milsom 2006 measured prevalence of dental caries as mean number of teeth with active caries in primary teeth (dt) and permanent teeth (DT); post-intervention changes from baseline were not significant, and the authors…
    1 study · 16684 participants
    GRADE not reported

Single-visit root canal treatment vs Multiple-visit root canal treatment (two or more visits)

Pain at 1 month · People aged 10 years or above requiring root canal treatment; permanent teeth with completely formed apex and without internal resorption
1 finding from 1 review

Glass ionomer-based sealant vs No sealant (control/no treatment)

Dental caries increment, DMFT/dmft (whole-tooth level) · Children with caries-free primary first molars (with or without caries on other teeth), aged 1-5 years (paediatric clinic/dental school,…
1 finding from 1 review
  • Sealants for preventing dental caries in primary teeth 2022 · Cochrane All outcomes
    12 months
    Joshi 2019: dmft 8.43 (SD 5.84) with sealant vs 10.05 (SD 6.16) with no sealant at 12 months (caries threshold uncertain); Chadwick 2005: no significant difference in caries increment on occlusal surfaces, no summary…
    2 studies
    GRADE not reported

Single-visit root canal treatment vs Multiple-visit root canal treatment (two or more visits)

Postobturation pain at 1 week · People aged 10 years or above requiring root canal treatment; permanent teeth with completely formed apex and without internal resorption

It is very uncertain whether single-visit root canal treatment changes postobturation pain at 1 week compared with multiple-visit root canal treatment (two or more visits) (very low certainty).

1 finding from 1 review

Traditional screening (referral card given if the inspecting dentist judges the child needs to see a dentist) vs No screening

Cost‐effectiveness · School children (aged 4 to 15 years), primary and secondary schools in the UK and India

The review found no eligible studies for this question.

1 finding from 1 review

Glass ionomer-based sealant vs Resin-based sealant

Adverse events · 'Healthy' children with caries-free second primary molars, aged 3-5 years (schools and kindergartens, India and China)
1 finding from 1 review
  • 1 study reported adverse events as some discomfort such as nausea; 1 child experienced a strong gag reflex following the glass ionomer-based sealant while 8 children reported feeling uncomfortable after the fluoride…
    1 study · 100 participants
    Very low

Periodontal treatment (subgingival instrumentation, with or without antimicrobials/surgery) vs usual care or no treatment

Resource implications (e.g. cost of incontinence management methods) · People with diabetes mellitus (type 1 or type 2, mostly type 2) and periodontitis, at least 16 years of age

The review found no eligible studies for this question.

1 finding from 1 review