What do systematic reviews say?

Mefenamic acid vs naproxen

• Non‐steroidal anti‐inflammatory drugs for heavy menstrual bleeding 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 35 participants
  Low

NSAIDs vs placebo control

The review found no eligible studies for this question.

• Non‐steroidal anti‐inflammatory drugs for heavy menstrual bleeding 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

NSAIDs vs tranexamic acid (control)

• Non‐steroidal anti‐inflammatory drugs for heavy menstrual bleeding 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 49 participants
  Low

Progestogen therapy (luteal phase only) vs other medical therapy

• Cyclical progestogens for heavy menstrual bleeding 2019 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 171 participants
  Very low

Progestogen therapy long cycle (3 to 4 weeks) vs other medical therapy

The review found no eligible studies for this question.

• Cyclical progestogens for heavy menstrual bleeding 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Mucolytic vs placebo

• Mucolytic agents versus placebo for chronic bronchitis or chronic obstructive pulmonary disease 2019 · Cochrane Headline outcomes only
  no estimate extracted
  9 studies · 2259 participants
  Moderate

Inhaled corticosteroids vs placebo

It is very uncertain whether summary of findings: inhaled corticosteroids changes respiratory exacerbations: number of days on intravenous antibiotics… compared with placebo (very low certainty).

• Inhaled corticosteroids for cystic fibrosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 17 participants
  Very low

Corticosteroids vs placebo or usual care

Corticosteroids probably leads to lower 28‐Day all‐cause mortalitya compared with placebo or usual care (moderate certainty).

• Corticosteroids for treating sepsis in children and adults 2019 · Cochrane Headline outcomes only
  RR 0.91 [0.84, 0.99]
  50 studies · 11233 participants
  Moderate

Corticosteroids vs placebo or usual care

• Corticosteroids for treating sepsis in children and adults 2019 · Cochrane Headline outcomes only
  no estimate extracted
  21 studies · 7612 participants
  High

Corticosteroids vs placebo or usual care

• Corticosteroids for treating sepsis in children and adults 2019 · Cochrane Headline outcomes only
  no estimate extracted
  22 studies · 8795 participants
  High

Formula vs donor breast milk

• Formula versus donor breast milk for feeding preterm or low birth weight infants 2019 · Cochrane Headline outcomes only
  no estimate extracted
  9 studies · 1028 participants
  Moderate

Bispectral index vs clinical signs

Bispectral index may leads to lower occurrence of intraoperative awareness Time points of measure after… compared with clinical signs (low certainty).

• Bispectral index for improving intraoperative awareness and early postoperative recovery in adults 2019 · Cochrane Headline outcomes only
  Peto OR 0.36 [0.21, 0.6]
  27 studies · 9765 participants
  Low

Bispectral index vs ETAG

BIS showed no clear difference in occurrence of intraoperative awareness Time points of measure after… compared with ETAG (low certainty).

• Bispectral index for improving intraoperative awareness and early postoperative recovery in adults 2019 · Cochrane Headline outcomes only
  Peto OR 1.13 [0.56, 2.26]
  5 studies · 26572 participants
  Low

Early enteral nutrition within 24 hours of lower gastrointestinal surgery vs later commencement

• Early enteral nutrition within 24 hours of lower gastrointestinal surgery versus later commencement for length of… 2019 · Cochrane Headline outcomes only
  no estimate extracted
  16 studies · 1346 participants
  Low

Intervention not reported

• Early enteral nutrition within 24 hours of lower gastrointestinal surgery versus later commencement for length of… 2019 · Cochrane Headline outcomes only
  no estimate extracted
  13 studies · 1156 participants
  Low

Intervention not reported

• Early enteral nutrition within 24 hours of lower gastrointestinal surgery versus later commencement for length of… 2019 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 190 participants
  Low

Intervention not reported

• Early enteral nutrition within 24 hours of lower gastrointestinal surgery versus later commencement for length of… 2019 · Cochrane Headline outcomes only
  no estimate extracted
  11 studies · 1075 participants
  Low

Intervention not reported

• Early enteral nutrition within 24 hours of lower gastrointestinal surgery versus later commencement for length of… 2019 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 271 participants
  Very low

Corticosteroids vs control

Corticosteroids showed no clear difference in early all‐cause mortality (≤ 3 months) Reported at: day 14; day 28;… compared with control (low certainty).

• Pharmacological agents for adults with acute respiratory distress syndrome 2019 · Cochrane Headline outcomes only
  RR 0.77 [0.57, 1.05]
  6 studies · 574 participants
  Low

Surfactants vs control

• Pharmacological agents for adults with acute respiratory distress syndrome 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 344 participants
  Very low