Cochrane · systematic review · CD002971

Formula versus donor breast milk for feeding preterm or low birth weight infants

Quigley, M, Embleton, ND, McGuire, W · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library

Neonatal2 versionsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 6 · 100%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

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Formula versus donor breast milk for feeding preterm or low birth weight infants

Population: preterm or low birth weight infants
6 questions
OutcomeEffectEvidenceStatus / GRADE
Weight gain (g/kg/day)
Formula vs donor breast milk
no estimate extracted9 studies · 1028 participantsModerate
Linear growth (crown‐heel length mm/week)
Formula vs donor breast milk
no estimate extracted8 studies · 820 participantsModerate
Head growth (mm/week)
Formula vs donor breast milk
no estimate extracted8 studies · 894 participantsModerate
Neurodevelopmental disability
Formula vs donor breast milk
RR 1.21 [0.62, 2.35]2 studies · 400 participantsModerate
All‐cause mortality
Formula vs donor breast milk
RR 1.1 [0.8, 1.5]7 studies · 1527 participantsModerate
Necrotising enterocolitis
Formula vs donor breast milk
RR 1.87 [1.23, 2.85]9 studies · 1675 participantsModerate