Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,256 questions · 2,339 findings · 262 reviews

No studies found 555 · 23.7%GRADE not reported 398 · 17%Very low 572 · 24.5%Low 476 · 20.4%Moderate 240 · 10.3%High 98 · 4.2%

Preoperative analgesics (analgesics given before dental treatment) vs Placebo or no analgesics

Intraoperative pain · Children and adolescents aged up to 17 years having dental treatment (orthodontic treatment, fillings, pulp treatment, or tooth…

The review found no eligible studies for this question.

1 finding from 1 review

Educational intervention with information and practical components (theoretical oral health education plus practical skills training) for nursing staff and/or residents vs (Optimised) usual care

Adverse effects of the interventions · Nursing home residents (mean age 78.3 to 86.0 years; more than 66% women; 62.1% to 87.3% with dental prostheses)

The review found no eligible studies for this question.

1 finding from 1 review

Preoperative analgesics (analgesics given before dental treatment) vs Placebo or no analgesics

Costs · Children and adolescents aged up to 17 years having dental treatment (orthodontic treatment, fillings, pulp treatment, or tooth…

The review found no eligible studies for this question.

1 finding from 1 review

Educational intervention with information and practical components (theoretical oral health education plus practical skills training) for nursing staff and/or residents vs (Optimised) usual care

Denture-induced stomatitis · Nursing home residents (mean age 78.3 to 86.0 years; more than 66% women; 62.1% to 87.3% with dental prostheses)
1 finding from 1 review

Educational intervention with information and practical components (theoretical oral health education plus practical skills training) for nursing staff and/or residents vs (Optimised) usual care

Gingivitis · Nursing home residents (mean age 78.3 to 86.0 years; more than 66% women; 62.1% to 87.3% with dental prostheses)
1 finding from 1 review

CHRONIC: ACEi or ARB vs placebo

All‐cause mortality · Patients undergoing any type of surgery under general anaesthesia receiving ACEIs or ARBs perioperatively

It is very uncertain whether ACEIs or ARBs changes all‐cause mortality compared with placebo (very low certainty).

1 finding from 1 review

CHRONIC: ACEi or ARB vs placebo

Risk of acute myocardial ischaemia · Patients undergoing any type of surgery under general anaesthesia receiving ACEIs or ARBs perioperatively

It is very uncertain whether ACEIs or ARBs changes risk of acute myocardial ischaemia compared with placebo (very low certainty).

1 finding from 1 review

CHRONIC: ACEi or ARB vs placebo

Rate of perioperative cerebrovascular complications · Patients undergoing any type of surgery under general anaesthesia receiving ACEIs or ARBs perioperatively

It is very uncertain whether ACEIs or ARBs changes rate of perioperative cerebrovascular complications compared with placebo (very low certainty).

1 finding from 1 review

Lidocaine vs placebo

Incidence of pain with lidocaine pretreatment Pain scales · adults and children undergoing general anaesthesia including the muscle relaxant rocuronium bromide

Lidocaine may leads to lower pain ‐ lidocaine compared with placebo (low certainty).

1 finding from 1 review

Summary of findings table ‐ Remifentanil vs placebo

Pain ‐ remifentanil · adults and children undergoing general anaesthesia including the muscle relaxant rocuronium bromide

Remifentanil may leads to lower pain ‐ remifentanil compared with placebo (low certainty).

1 finding from 1 review

Adverse effects of pharmacological intervention vs control

Breath holding · adults and children undergoing general anaesthesia including the muscle relaxant rocuronium bromide

It is very uncertain whether adverse effects of pharmacological intervention changes breath holding compared with control (very low certainty).

1 finding from 1 review

Adverse effects of pharmacological intervention vs control

Cough · adults and children undergoing general anaesthesia including the muscle relaxant rocuronium bromide

Adverse effects of pharmacological intervention may leads to higher cough compared with control (low certainty).

1 finding from 1 review

Adverse effects of pharmacological intervention vs control

Adverse effects: pain on injection (solution deposition), Heft-Parker VAS 0-170 mm · adults and children undergoing general anaesthesia including the muscle relaxant rocuronium bromide

Adverse effects of pharmacological intervention showed no clear difference in pain on injection compared with control (low certainty).

1 finding from 1 review