Cochrane · systematic review · CD009346
Pharmacological and non‐pharmacological interventions for reducing rocuronium bromide induced pain on injection in children and adults
Prabhakar, H, Singh, GP, Ali, Z, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
AnaesthesiaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 28.6%Low 5 · 71.4%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Lidocaine versus placebo for reducing rocuronium bromide induced pain on injection
Population: adults and children undergoing general anaesthesia including the muscle relaxant rocuronium bromide
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain ‐ lidocaine Lidocaine vs placebo | RR 0.23 [0.17, 0.31] | 29 studies · 2256 participants | Low Downgraded: risk of bias, inconsistency |
Fentanyl versus placebo for reducing rocuronium bromide induced pain on injection
Population: adults and children undergoing general anaesthesia including the muscle relaxant rocuronium bromide
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain ‐ fentanyl Fentanyl vs placebo | RR 0.42 [0.26, 0.7] | 7 studies · 514 participants | Low Downgraded: risk of bias, inconsistency |
Remifentanil versus placebo for reducing rocuronium bromide induced pain on injection
Population: adults and children undergoing general anaesthesia including the muscle relaxant rocuronium bromide
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain ‐ remifentanil Remifentanil vs placebo | RR 0.1 [0.04, 0.26] | 7 studies · 494 participants | Low Downgraded: risk of bias, inconsistency |
Adverse effects of pharmacological intervention versus control for reducing rocuronium induced pain on injection
Population: adults and children undergoing general anaesthesia including the muscle relaxant rocuronium bromide
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Breath holding Adverse effects of pharmacological intervention vs control | RR 1.19 [0.12, 11.65] | 2 studies · 279 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Chest tightness Adverse effects of pharmacological intervention vs control | RR 2.61 [0.12, 56.03] | 1 study · 90 participants | Very low Downgraded: risk of bias, imprecision |
Cough Adverse effects of pharmacological intervention vs control | RR 9 [2.77, 29.29] | 5 studies · 529 participants | Low Downgraded: risk of bias, inconsistency |
Pain on injection Adverse effects of pharmacological intervention vs control | RR 0.47 [0.09, 2.46] | 1 study · 118 participants | Low Downgraded: risk of bias, imprecision |