Search review questions

Blood loss (total) · participants undergoing surgery

All‐cause mortality · participants undergoing surgery

All thrombotic events (including myocardial infarction, ischaemic stroke, other arterial thromboembolism, and venous thromboembolism) · participants undergoing surgery

Quality of life · participants undergoing surgery

Blood loss (total) · participants undergoing surgery

All‐cause mortality · participants undergoing surgery

All thrombotic events (including myocardial infarction, ischaemic stroke, other arterial thromboembolism, and venous thromboembolism) · participants undergoing surgery

Quality of life · participants undergoing surgery

Red cell volume transfused (total) · participants with platelet dysfunction undergoing surgery

Number of participants receiving a red cell transfusion (total) · participants with platelet dysfunction undergoing surgery

Blood loss (total) · participants with platelet dysfunction undergoing surgery

Cardiorespiratory fitness ‐ peak power output (W) ‐ end of intervention · people with traumatic brain injury of any age or severity

Depression ‐ SMD ‐ end of intervention · people with traumatic brain injury of any age or severity

Cognition · people with traumatic brain injury of any age or severity

Fatigue ‐ SMD ‐ end of intervention · people with traumatic brain injury of any age or severity

Community integration · people with traumatic brain injury of any age or severity

Safety · people with traumatic brain injury of any age or severity

Spasticity at up to 6 hours after treatment (measured by the Ashworth Scale, 0‐, with a higher score indicating greater spasticity) · adults with traumatic brain injury with spasticity in their arms and legs

Sensory functions and pain · adults with traumatic brain injury with spasticity in their arms (1 study) or calves (1 study)

Neuromusculoskeletal and movement‐related functions at 12 weeks (measured by ankle dorsiflexion) · adults with traumatic brain injury with spasticity in their arms (1 study) or calves (1 study)

General tasks and demands · adults with traumatic brain injury with spasticity in their arms (1 study) or calves (1 study)

Mobility · adults with traumatic brain injury with spasticity in their arms (1 study) or calves (1 study)

Self‐care · adults with traumatic brain injury with spasticity in their arms (1 study) or calves (1 study)

Spasticity at up to 6 hours after treatment (measured by the Modified Ashworth Scale, 0‐4, with a higher score indicating greater spasticity) · children/young people aged 4‐18 years with traumatic brain injury and with 'mild to severe spastic tetraparesis'…

Adverse events · children/young people aged 4‐18 years with traumatic brain injury and with 'mild to severe spastic tetraparesis'…

Sensory functions and pain · children/young people aged 4‐18 years with traumatic brain injury and with 'mild to severe spastic tetraparesis'…

Neuromusculoskeletal and movement‐related functions post treatment (measured by range of movement) · children/young people aged 4‐18 years with traumatic brain injury and with 'mild to severe spastic tetraparesis'…

General tasks and demands · children/young people aged 4‐18 years with traumatic brain injury and with 'mild to severe spastic tetraparesis'…

Adverse events · adults with traumatic brain injury with spasticity in their arms and legs

Mobility · children/young people aged 4‐18 years with traumatic brain injury and with 'mild to severe spastic tetraparesis'…

Self‐care · children/young people aged 4‐18 years with traumatic brain injury and with 'mild to severe spastic tetraparesis'…

Sensory functions and pain · adults with traumatic brain injury with spasticity in their arms and legs

Neuromusculoskeletal and movement‐related functions up to 6 hours after treatment (Measured by spasm and deep tendon reflex scores, 0‐5, with 0 being no reflexes and 5 being clonus, or repeated involuntary muscle contractions) · adults with traumatic brain injury with spasticity in their arms and legs

General tasks and demands · adults with traumatic brain injury with spasticity in their arms and legs

Mobility · adults with traumatic brain injury with spasticity in their arms and legs

Self‐care · adults with traumatic brain injury with spasticity in their arms and legs

Spasticity at 4‐12 weeks (measured by both Modified Ashworth Scale, 0‐5, at 12 weeks and Tardieu Scale, 0‐5, at 4 weeks) · adults with traumatic brain injury with spasticity in their arms (1 study) or calves (1 study)

Adverse events · adults with traumatic brain injury with spasticity in their arms (1 study) or calves (1 study)

Mortality · people with severe traumatic brain injury (adults and children)

Intracranial pressure (ICP) · people with severe traumatic brain injury (adults and children)

Cerebral perfusion pressure (CPP) · people with severe traumatic brain injury (adults and children)

Quality of life; Glasgow Coma Score; Disability · people with severe traumatic brain injury (adults and children)

Adverse events · people with severe traumatic brain injury (adults and children)

Mortality at end of scheduled · people with acute TBI secondary to head injury

Disability (unfavourable outcomes: death, vegetative state, severe disability; GOS 1‐3) at end of scheduled · people with acute TBI secondary to head injury

Intracranial pressure (ICP) within the treatment period · people with acute TBI secondary to head injury

Blood pressure · people with acute TBI secondary to head injury

Body temperature · people with acute TBI secondary to head injury

Adverse events · people with acute TBI secondary to head injury

Self‐reported medically or non‐medically attended unintentional injuries or injuries with an unspecified intent (injury rates adjusted for clustering) · children and young people