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Search review questions
Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
611 questions in 50 reviews · Injuries
current versionsNo studies 125 · 20.5%Ungraded 22 · 3.6%Very low 185 · 30.3%Low 171 · 28%Moderate 77 · 12.6%High 31 · 5.1%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Intervention NR Frequency of wearing a seat belt assessed through self‐report · drivers or passengers travelling in passenger or commercial vehicles Education, incentive, and engineering‐based interventions to promote the use of seat belts (2024) · Cochrane | no estimate extracted | 3 studies · 986 participants | Low |
Intervention NR Crash‐related injury rates · drivers or passengers travelling in passenger or commercial vehicles Education, incentive, and engineering‐based interventions to promote the use of seat belts (2024) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Crash‐related mortality rates · drivers or passengers travelling in passenger or commercial vehicles Education, incentive, and engineering‐based interventions to promote the use of seat belts (2024) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Frequency of wearing a seat belt · drivers or passengers travelling in passenger or commercial vehicles Education, incentive, and engineering‐based interventions to promote the use of seat belts (2024) · Cochrane | no estimate extracted | 2 studies · 1407 participants | Low |
Intervention NR Crash‐related injury rates · drivers or passengers travelling in passenger or commercial vehicles Education, incentive, and engineering‐based interventions to promote the use of seat belts (2024) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Crash‐related mortality rates · drivers or passengers travelling in passenger or commercial vehicles Education, incentive, and engineering‐based interventions to promote the use of seat belts (2024) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Frequency of wearing a seat belt · drivers or passengers travelling in passenger or commercial vehicles Education, incentive, and engineering‐based interventions to promote the use of seat belts (2024) · Cochrane | no estimate extracted | 2 studies · 118 participants | Low |
Intervention NR Crash‐related injury rates · drivers or passengers travelling in passenger or commercial vehicles Education, incentive, and engineering‐based interventions to promote the use of seat belts (2024) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Crash‐related mortality rates · drivers or passengers travelling in passenger or commercial vehicles Education, incentive, and engineering‐based interventions to promote the use of seat belts (2024) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Total studies: 47 Total participants: 4398 · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 47 participants | Ungraded |
Intervention NR TXA given intra‐articularly at a total dose of 2 g intraoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 2 participants | Low |
Intervention NR TXA given intravenously at a total dose of 1 g intraoperatively and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 1 participants | Low |
Intervention NR TXA given orally at a total dose of greater than 3 g pre‐incision and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 3 participants | Very low |
Intervention NR TXA given orally at a total dose of 2 g pre‐incision · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 2 participants | Low |
Intervention NR TXA given intra‐articularly at a total dose of 1 g intraoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 1 participants | Low |
Intervention NR TXA given intravenously at a total dose of greater than 3 g intraoperatively and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 3 participants | Moderate |
Intervention NR TXA given intravenously and intra‐articularly at a total dose of 2 g pre‐incision and intraoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 2 participants | Very low |
Intervention NR TXA given orally at a total dose of 2 g pre‐incision and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 2 participants | Low |
Intervention NR TXA given intravenously at a total dose of 2 g pre‐incision and intraoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 2 participants | Very low |
Intervention NR TXA given intravenously at a total dose of 1 g pre‐incision and intraoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 1 participants | Moderate |
Intervention NR TXA given orally and intra‐articularly at a total dose of greater than 3 g pre‐incision, intraoperatively and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 3 participants | Moderate |
Intervention NR Aprotinin given intravenously · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | NR | Low |
Intervention NR Desmopressin given intravenously · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | NR | Low |
Intervention NR EACA given intravenously · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | NR | Very low |
Intervention NR Fibrin (topical) · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | NR | Very low |
Intervention NR TXA given intravenously at a total dose of 1 g intraoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 1 participants | Low |
Intervention NR TXA given intravenously at a total dose of 1 g pre‐incision · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 1 participants | Moderate |
Intervention NR TXA given intravenously at a total dose of 1 g pre‐incision, intraoperatively and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 1 participants | Low |
Intervention NR TXA given intravenously at a total dose of 2 g intraoperatively and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 2 participants | Low |
Intervention NR TXA given intravenously at a total dose of 2 g pre‐incision and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 2 participants | Moderate |
Intervention NR TXA given intravenously at a total dose of 3 g intraoperatively and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 3 participants | Moderate |
Intervention NR TXA given orally at a total dose of 3 g pre‐incision and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 3 participants | Low |
Intervention NR Total studies: 19 Total participants: 2395 · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 19 participants | Ungraded |
Intervention NR TXA given intravenously and orally at a total dose of greater than 3 g intraoperatively and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 3 participants | Low |
Intervention NR TXA given intravenously and intra‐articularly at a total dose of 2 g pre‐incision and intraoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 2 participants | Low |
Intervention NR TXA given intravenously and intra‐articularly at a total dose of greater than 3 g pre‐incision, intraoperatively and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 3 participants | Low |
Intervention NR TXA given intravenously at a total dose of greater than 3 g intraoperatively and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 3 participants | Low |
Intervention NR TXA given intravenously and orally at a total dose of greater than 3 g pre‐incision and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 3 participants | Low |
Intervention NR TXA given intravenously at a total dose of 3 g intraoperatively and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 3 participants | Low |
Intervention NR TXA given intra‐articularly at a total dose of 2 g intraoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 2 participants | Low |
Intervention NR TXA given orally and intra‐articularly at a total dose of greater than 3 g pre‐incision, intraoperatively and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 3 participants | Low |
Intervention NR TXA given intravenously at a total dose of 2 g pre‐incision and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 2 participants | Low |
Intervention NR TXA given intravenously and orally at a total dose of greater than 3 g intraoperatively and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 3 participants | Low |
Intervention NR TXA given intravenously at a total dose of 1 g postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 1 participants | Low |
Intervention NR TXA given intravenously at a total dose of 2 g postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 2 participants | Low |
Intervention NR TXA given intravenously at a total dose of 2 g intraoperatively and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 2 participants | Very low |
Intervention NR Aprotinin given intravenously · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | NR | Very low |
Intervention NR TXA given intra‐articularly at a total dose of 1 g intraoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 1 participants | Low |
Intervention NR TXA given intravenously at a total dose of 1 g pre‐incision · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 1 participants | Low |
Intervention NR TXA given intravenously at a total dose of 1 g pre‐incision and intraoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 1 participants | Low |