Respiratory distress syndrome · infants born of women at risk of preterm birth
Neonatal and child outcomes: corticosteroids leads to lower respiratory distress syndrome№ of participants: 11,183(26 RCTs) compared with placebo or no treatment (high certainty).
1 finding from 1 review
RR 0.71 [0.65, 0.78]
Studies not reported
High
Intraventricular haemorrhage · infants born of women at risk of preterm birth
Neonatal and child outcomes: corticosteroids probably leads to lower intraventricular haemorrhage (IVH)№ of participants: 8475(12 RCTs) compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
RR 0.58 [0.45, 0.75]
Studies not reported
Moderate
Developmental delay in childhood№ of participants: 600 (3 RCTs). Age at · infants born of women at risk of preterm birth
Neonatal and child outcomes: corticosteroids probably leads to lower developmental delay in childhood№ of participants: 600 (3 RCTs). Age… compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
RR 0.51 [0.27, 0.97]
Studies not reported
Moderate
Maternal death · women at risk of preterm birth
Maternal outcomes: corticosteroids showed no clear difference in maternal death compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
RR 1.19 [0.36, 3.89]
Studies not reported
Moderate
Chorioamnionitis · women at risk of preterm birth
Maternal outcomes: corticosteroids showed no clear difference in chorioamnionitis№ of participants: 8374(15 RCTs) compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
RR 0.86 [0.69, 1.08]
Studies not reported
Moderate
Endometritis · women at risk of preterm birth
Maternal outcomes: corticosteroids showed no clear difference in endometritis№ of participants: 6764(10 RCTs) compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
RR 1.14 [0.82, 1.58]
Studies not reported
Moderate
Perinatal loss: all ‐ including miscarriages and stillbirth (Note: data not available for neonatal death)
It is very uncertain whether cervical cerclage in combination with antibiotics and tocolytics changes perinatal loss: all ‐ including miscarriages and stillbirth (Note:… compared with cervical cerclage alone (very low certainty).
1 finding from 1 review
Stillbirth (death after 24 weeks inutero)
1 finding from 1 review
Perinatal mortality · women at risk of preterm birth
Strategies to increase use of antenatal corticosteroids probably leads to higher perinatal death (at population level) compared with routine (usual) care (moderate certainty).
1 finding from 1 review
Offspring mortality, early neurodevelopmental morbidity or late neurodevelopmental morbidity · women at risk of preterm birth
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Offspring mortality or severe neonatal morbidity · women at risk of preterm birth
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Neonatal death (death within the first 28 days of life) · women at risk of preterm birth
Strategies to increase use of antenatal corticosteroids probably leads to higher neonatal death before 28 days (at population level) compared with routine (usual) care (moderate certainty).
1 finding from 1 review
Appropriate ACS treatment (women) · women at risk of preterm birth
Strategies to increase use of antenatal corticosteroids may leads to higher appropriate ACS treatment (women) compared with routine (usual) care (low certainty).
1 finding from 1 review
Inappropriate ACS treatment (women) · women at risk of preterm birth
Strategies to increase use of antenatal corticosteroids may leads to higher inappropriate ACS treatment (women) compared with routine (usual) care (low certainty).
1 finding from 1 review
Maternal infection or inflammation (at population level) · women at risk of preterm birth
Strategies to increase use of antenatal corticosteroids may leads to higher maternal infection or inflammation (at population level) compared with routine (usual) care (low certainty).
1 finding from 1 review
Maternal death · women at risk of preterm birth
Strategies to increase use of antenatal corticosteroids showed no clear difference in maternal mortality (at population level) compared with routine (usual) care (low certainty).
1 finding from 1 review
Low birthweight · Women with a multiple pregnancy
Vaginal progesterone showed no clear difference in infant birthweight less than 2500 g compared with no treatment or placebo (moderate certainty).
1 finding from 1 review
Low birthweight · Women with a multiple pregnancy
Intramuscular (IM) progesterone showed no clear difference in infant birthweight less than 2500 g compared with no treatment or placebo (moderate certainty).
1 finding from 1 review
All perinatal losses · preventing preterm birth in women with singleton pregnancy
Cerclage showed no clear difference in all perinatal losses compared with no cerclage (moderate certainty).
1 finding from 1 review
Serious neonatal morbidity · preventing preterm birth in women with singleton pregnancy
Cerclage showed no clear difference in serious neonatal morbidity compared with no cerclage (low certainty).
1 finding from 1 review