Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

236 questions · 242 findings · 34 reviews · Headline outcomes only

No studies found 85 · 35.1%GRADE not reported 4 · 1.7%Very low 58 · 24%Low 52 · 21.5%Moderate 36 · 14.9%High 7 · 2.9%

Summary of findings table ‐ Protein, arginine, zinc and antioxidants vs standard diet or placebo

Time to complete healing of pressure ulcers ‐ not reported · residents of long‐term care (≥ 65 years) with pressure ulcers; inpatients with pressure ulcers

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings table ‐ Protein, arginine, zinc and antioxidants vs standard diet or placebo

Acceptability of nutritional supplements ‐ not reported · residents of long‐term care (≥ 65 years) with pressure ulcers; inpatients with pressure ulcers

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings table ‐ Protein, arginine, zinc and antioxidants vs standard diet or placebo

Gastrointestinal adverse events · residents of long‐term care (≥ 65 years) with pressure ulcers; inpatients with pressure ulcers

It is very uncertain whether summary of findings table ‐ Protein, arginine, zinc and antioxidants changes side effects: at least one adverse gastrointestinal event compared with standard diet or placebo (very low certainty).

1 finding from 1 review

Primary objective: mobile stock notification with effective product transport vs usual care

Proportion of healthcare workers who reported a stockout of drugs in the last 30 days (stockout of zinc 20 mg to treat diarrhoea) · healthcare workers and other health professionals involved in commodity and stock management

It is very uncertain whether primary objective: mobile stock notification with effective product… changes proportion of healthcare workers who reported a stockout of drugs in… compared with standard care (very low certainty).

1 finding from 1 review

Primary objective: mobile stock notification with enhanced management vs usual care

Proportion of healthcare workers who reported a stockout of drugs in the last 30 days (stockout of zinc 20 mg to treat diarrhoea) · healthcare workers and other health professionals involved in commodity and stock management

It is very uncertain whether primary objective: mobile stock notification with enhanced management changes proportion of healthcare workers who reported a stockout of drugs in… compared with standard care (very low certainty).

1 finding from 1 review

NMA evidence for individual network: proportion with complete healing ‐ interventions vs saline gauze

Polyvinylpyrrolidone + zinc oxide · people with pressure ulcers

NMA evidence for individual network: proportion with complete… showed no clear difference in polyvinylpyrrolidone + zinc oxide compared with saline gauze (low certainty).

1 finding from 1 review

Dietary supplements vs placebo

Zinc sulphate versus placebo Adverse effects · women with moderate or severe primary dysmenorrhoea

It is very uncertain whether dietary supplements changes zinc sulphate versus placebo Adverse effects compared with placebo (very low certainty).

1 finding from 1 review

Any topical skin care product vs another topical skin care product

Number of participants with IAD (new) · adults with urinary incontinence

Any topical skin care product showed no clear difference in number of participants with IAD (new) (2) Sudocrem (A) versus zinc… compared with another topical skin care product (low certainty).

1 finding from 1 review

Topical ketanserin (2%) vs clioquinol cream (3%) or zinc paste

Ulcer healing · ulceration caused by nerve damage in leprosy

It is very uncertain whether topical ketanserin (2%) changes primary outcome: healing of ulcers (healing of ulcer at 3 months) compared with clioquinol cream (3%) or zinc paste (very low certainty).

1 finding from 1 review