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Evidence found and GRADE certainty

229 questions · 231 findings · 28 reviews

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No studies found 32 · 13.9%GRADE not reported 3 · 1.3%Very low 28 · 12.1%Low 58 · 25.1%Moderate 60 · 26%High 50 · 21.6%

Inhaled corticosteroids plus standard care vs placebo or usual care

All‐cause mortality · adults with a confirmed diagnosis of mild COVID‐19, of whom only 10% (219/2132) participants had received ≥ 1 vaccination

Inhaled corticosteroids plus standard care showed no clear difference in all‐cause mortality compared with standard care (with or without placebo) (low certainty).

1 finding from 1 review

Inhaled corticosteroids plus standard care vs placebo or usual care

Admission to hospital or death · adults with a confirmed diagnosis of mild COVID‐19, of whom only 10% (219/2132) participants had received ≥ 1 vaccination

Inhaled corticosteroids plus standard care probably leads to lower admission to hospital or death compared with standard care (with or without placebo) (moderate certainty).

1 finding from 1 review

Inhaled corticosteroids plus standard care vs placebo or usual care

Resolution of symptoms · adults with a confirmed diagnosis of mild COVID‐19, of whom only 10% (219/2132) participants had received ≥ 1 vaccination

Inhaled corticosteroids plus standard care probably leads to higher symptom resolution: all initial symptoms resolved at day 14 compared with standard care (with or without placebo) (moderate certainty).

1 finding from 1 review

Inhaled corticosteroids plus standard care vs placebo or usual care

Time to symptom resolution · adults with a confirmed diagnosis of mild COVID‐19, of whom only 10% (219/2132) participants had received ≥ 1 vaccination

Inhaled corticosteroids plus standard care showed no clear difference in symptom resolution: duration to symptoms resolved compared with standard care (with or without placebo) (low certainty).

1 finding from 1 review

Inhaled corticosteroids plus standard care vs placebo or usual care

Serious adverse events · adults with a confirmed diagnosis of mild COVID‐19, of whom only 10% (219/2132) participants had received ≥ 1 vaccination

It is very uncertain whether inhaled corticosteroids plus standard care changes serious adverse events compared with standard care (with or without placebo) (very low certainty).

1 finding from 1 review

Inhaled corticosteroids plus standard care vs placebo or usual care

Adverse events · adults with a confirmed diagnosis of mild COVID‐19, of whom only 10% (219/2132) participants had received ≥ 1 vaccination

Inhaled corticosteroids plus standard care showed no clear difference in adverse events compared with standard care (with or without placebo) (low certainty).

1 finding from 1 review

Inhaled corticosteroids plus standard care vs placebo or usual care

Infections · adults with a confirmed diagnosis of mild COVID‐19, of whom only 10% (219/2132) participants had received ≥ 1 vaccination

Inhaled corticosteroids plus standard care showed no clear difference in infections compared with standard care (with or without placebo) (low certainty).

1 finding from 1 review

LHWs to promote immunisation uptake in children vs usual care

Immunisation schedule up to date Interviews with mothers, record reviews · patients with improving immunisation uptake among children < 2 years whose vaccination is not up to date

LHWs to promote immunisation uptake in children probably leads to higher immunisation schedule up to date Interviews with mothers, record… compared with usual care (moderate certainty).

1 finding from 1 review