Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,520 questions · 1,575 findings · 175 reviews · Headline outcomes only

No studies found 239 · 15.2%GRADE not reported 59 · 3.7%Very low 337 · 21.4%Low 406 · 25.8%Moderate 410 · 26%High 124 · 7.9%

Corticosteroids vs placebo

Improvement in sensory nerve function at 1 year · people with nerve damage (< 6 months' duration) in leprosy

Corticosteroids showed no clear difference in improvement in sensory nerve function at 1 year Defined as a… compared with placebo (moderate certainty).

1 finding from 1 review

Corticosteroids vs placebo

Change in nerve pain and in nerve tenderness at 1 year ‐ not reported · people with nerve damage (6 to 24 months' duration) in leprosy

The review found no eligible studies for this question.

1 finding from 1 review

Corticosteroids vs placebo

Adverse effects requiring withdrawal/discontinuation of study medication · people with nerve damage (6 to 24 months' duration) in leprosy

Corticosteroids showed no clear difference in adverse events Assessed as adverse events requiring withdrawal of… compared with placebo (moderate certainty).

1 finding from 1 review

Corticosteroids vs placebo

Adverse events Assessed as: occurrence of one or more major adverse events requiring withdrawal of treatment · people with nerve damage (< 6 months' duration) in leprosy

Corticosteroids showed no clear difference in adverse events Assessed as: occurrence of one or more major adverse… compared with placebo (moderate certainty).

1 finding from 1 review