Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

564 questions · 589 findings · 155 reviews · Headline outcomes only

No studies found 114 · 19.4%GRADE not reported 15 · 2.5%Very low 179 · 30.4%Low 141 · 23.9%Moderate 110 · 18.7%High 30 · 5.1%

Summary of findings table ‐ Cognitive behavioural therapy plus standard care vs control

Leaving the study early ‐ for any reason ‐ overall acceptability (combined time points) · recent‐onset psychosis (less than three years since the start of psychotic symptoms and either first or second psychotic episode)

Summary of findings table ‐ Cognitive behavioural therapy plus… showed no clear difference in leaving the study early ‐ for any reason ‐ overall acceptability… compared with control (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ CBT without antipsychotics vs CBT plus antipsychotics

Leaving the study early/ loss to · schizophrenia

It is very uncertain whether summary of findings table ‐ CBT without antipsychotics changes leaving the study early ‐ for any reason ‐ overall acceptability… compared with CBT plus antipsychotics (very low certainty).

1 finding from 1 review

Summary of findings table ‐ CBT without antipsychotics vs no specific treatment

Leaving the study early/ loss to · schizophrenia

Summary of findings table ‐ CBT without antipsychotics showed no clear difference in leaving the study early ‐ for any reason ‐ overall acceptability… compared with no specific treatment (low certainty).

1 finding from 1 review

Summary of findings table ‐ CBT without antipsychotics vs antipsychotics

Leaving the study early/ loss to · schizophrenia

It is very uncertain whether summary of findings table ‐ CBT without antipsychotics changes leaving the study early ‐ for any reason ‐ overall acceptability… compared with antipsychotics (very low certainty).

1 finding from 1 review

Culturally and literacy adapted audio‐/visual education without personal feedback vs written information on the same topic

Health behaviour – Time point a: medium‐term (up to 6 months post‐intervention) Any cancer screening uptake · migrants

Culturally and literacy adapted audio‐/visual education without… showed no clear difference in health behaviour – Time point a: medium‐term (up to 6 months… compared with written information on the same topic (low certainty).

1 finding from 1 review

Intratympanic corticosteroids vs systemic corticosteroids

Change in hearing threshold determined by PTA Range 0 dB to 140 dB Negative values represent lowering and positive values represent raising of the hearing threshold. A lower hearing threshold represents hearing improvement. Â · sudden sensorineural hearing loss

Intratympanic corticosteroids showed no clear difference in change in hearing threshold determined by PTA Range 0 dB to 140 dB… compared with systemic corticosteroids (low certainty).

1 finding from 1 review

Intratympanic plus systemic corticosteroids (combined therapy) vs systemic corticosteroids alone

Change in hearing threshold determined by PTA Range 0 dB to 140 dB Negative values represent lowering and positive values represent raising of the hearing threshold. A lower hearing threshold represents hearing improvement. Â · sudden sensorineural hearing loss

Intratympanic plus systemic corticosteroids (combined therapy) showed no clear difference in change in hearing threshold determined by PTA Range 0 dB to 140 dB… compared with systemic corticosteroids alone (low certainty).

2 findings from 1 review

Intratympanic plus systemic corticosteroids (combined therapy) vs systemic corticosteroids alone

Final hearing threshold determined by PTA (a lower value represents better hearing) · sudden sensorineural hearing loss

It is very uncertain whether intratympanic plus systemic corticosteroids (combined therapy) changes final hearing threshold determined by PTA A lower value represents… compared with systemic corticosteroids alone (very low certainty).

2 findings from 1 review

Intratympanic corticosteroids vs no treatment or versus placebo

Change in hearing threshold determined by PTA Range 0 dB to 140 dB Negative values represent lowering and positive values represent raising of the hearing threshold. A lower hearing threshold represents hearing improvement. Â · sudden sensorineural hearing loss

Intratympanic corticosteroids showed no clear difference in change in hearing threshold determined by PTA Range 0 dB to 140 dB… compared with no treatment or versus placebo (low certainty).

1 finding from 1 review

Intratympanic corticosteroids vs no treatment or versus placebo

Final hearing threshold determined by PTA (a lower value represents better hearing) · sudden sensorineural hearing loss

Intratympanic corticosteroids showed no clear difference in final hearing threshold determined by PTA (a lower value represents… compared with no treatment or versus placebo (low certainty).

1 finding from 1 review

Intratympanic corticosteroids vs systemic corticosteroids

Final hearing threshold determined by PTA (a lower value represents better hearing) · sudden sensorineural hearing loss

Intratympanic corticosteroids showed no clear difference in final hearing threshold determined by PTA (a lower value represents… compared with systemic corticosteroids (low certainty).

1 finding from 1 review