Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

168 questions · 185 findings · 32 reviews

No studies found 41 · 22.2%GRADE not reported 10 · 5.4%Very low 48 · 25.9%Low 63 · 34.1%Moderate 20 · 10.8%High 3 · 1.6%

Intraperitoneal lidocaine instillation vs IM morphine

Number of women requiring rescue medication · women undergoing PPTL under local anaesthesia

Intraperitoneal lidocaine instillation may leads to lower number of women requiring rescue medication compared with intramuscular morphine (low certainty).

1 finding from 1 review

Methadone vs morphine

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · people with cancer pain

Methadone may leads to higher participant‐reported pain intensity compared with morphine (low certainty).

1 finding from 1 review

Methadone vs morphine

Adverse events: appetite, thirst, somnolence · people with cancer pain
1 finding from 1 review

Tramadol vs morphine

Additional analgesia required (escape analgesia) · children undergoing surgery

Tramadol showed no clear difference in number of patients requiring rescue analgesia (PACU) compared with morphine (low certainty).

2 findings from 1 review

Tramadol vs morphine

Proportion of participants with moderate to severe pain up to 6 hours after the procedure · children undergoing surgery

The review found no eligible studies for this question.

1 finding from 1 review