Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

633 questions · 668 findings · 122 reviews · Headline outcomes only

No studies found 144 · 21.6%GRADE not reported 27 · 4%Very low 154 · 23.1%Low 194 · 29%Moderate 119 · 17.8%High 30 · 4.5%

Tacrolimus vs mycophenolate mofetil to maintain remission

Primary outcome: partial clinical response · idiopathic steroid‐resistant nephrotic syndrome in children

Tacrolimus showed no clear difference in number with partial response at one year compared with mycophenolate mofetil to maintain remission (low certainty).

1 finding from 1 review

Tacrolimus vs mycophenolate mofetil to maintain remission

Number with steroid resistance by one year · idiopathic steroid‐resistant nephrotic syndrome in children

Tacrolimus showed no clear difference in number with steroid resistance by one year compared with mycophenolate mofetil to maintain remission (low certainty).

1 finding from 1 review

Macrolides vs doxycycline

Treatment failure · adults and adolescents with scrub typhus

It is very uncertain whether macrolides changes treatment failure compared with doxycycline (very low certainty).

1 finding from 1 review

Macrolides vs doxycycline

Resolution of fever within 48 hours · adults and adolescents with scrub typhus

It is very uncertain whether macrolides changes resolution of fever within 48 hours compared with doxycycline (very low certainty).

1 finding from 1 review

Macrolides vs doxycycline

Resolution of fever within 5 days · adults and adolescents with scrub typhus

Macrolides showed no clear difference in resolution of fever within 5 days compared with doxycycline (low certainty).

1 finding from 1 review

Gastrointestinal adverse events in people taking macrolide antibiotics vs placebo

Gastrointestinal disorders not otherwise specified · any indication

Gastrointestinal adverse events in people taking macrolide antibiotics probably leads to higher gastrointestinal disorders not otherwise specified compared with placebo (moderate certainty).

1 finding from 1 review