Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,776 questions · 7,311 findings · 959 reviews · Headline outcomes only

No studies found 1,498 · 20.5%GRADE not reported 303 · 4.1%Very low 1,839 · 25.2%Low 1,991 · 27.2%Moderate 1,277 · 17.5%High 403 · 5.5%

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Inhaled NO vs control

Death or use of ECMO; studies that did not allow back‐up use of iNO in controls · respiratory failure in infants born at or near term

Inhaled NO leads to lower death or use of ECMO; studies that did not allow back‐up use of iNO… compared with control (high certainty).

1 finding from 1 review

Outcomes for all interventions for smoking cessation in pregnancy vs control: subgrouped by main intervention strategy (comparison 20)

Birthweight < 2500 (g) · Pregnant women who smoke

Outcomes for all interventions for smoking cessation in pregnancy leads to lower low birthweight (under 2500 g) compared with control: subgrouped by main intervention strategy (comparison 20) (high certainty).

1 finding from 1 review

Intervention not reported

PIPP score during drug infusion Range of scale 0‐21 for infants < 28 weeks' PMA and 0‐18 for infants > 36 weeks' PMA. Lower score = less pain (Stevens 1996) · neonates requiring intubation and ventilation

The intervention showed no clear difference in PIPP score during drug infusion Range of scale 0‐21 for infants < 28… (moderate certainty).

1 finding from 1 review

Intervention not reported

PIPP score during drug infusion Range of scale 0‐21 for infants < 28 weeks' PMA and 0‐18 for infants > 36 weeks' PMA. Lower score = less pain (Stevens 1996) · neonates requiring intubation and ventilation

The intervention showed no clear difference in PIPP score during drug infusion Range of scale 0‐21 for infants < 28… (moderate certainty).

1 finding from 1 review

Intervention not reported

Low birthweight · HIV‐positive women during pregnancy and immediate postpartum period

The intervention probably leads to lower low birthweight (moderate certainty).

1 finding from 1 review

Recombinant luteinizing hormone (rLH) combined with recombinant follicle‐stimulating hormone (rFSH) vs rFSH alone

Cancellation rate for low response · Women undergoing ovarian stimulation with gonadotrophins in IVF and ICSI procedures

Recombinant luteinizing hormone (rLH) combined with recombinant… showed no clear difference in cancellation rate for low response compared with rFSH alone (low certainty).

1 finding from 1 review

Admission cardiotocography vs intermittent auscultation

Rate of caesarean section · Low risk pregnant women. All of the women were in labour.

Admission cardiotocography showed no clear difference in incidence of caesarean section compared with intermittent auscultation (low‐risk women) (moderate certainty).

1 finding from 1 review

Admission cardiotocography vs intermittent auscultation

Instrumental vaginal birth · Low risk pregnant women. All of the women were in labour.

Admission cardiotocography showed no clear difference in incidence of operative vaginal birth compared with intermittent auscultation (low‐risk women) (low certainty).

1 finding from 1 review

Admission cardiotocography vs intermittent auscultation

Perinatal mortality rate (fetal and neonatal deaths excluding lethal congenital anomalies) · Low risk pregnant women. All of the women were in labour.

Admission cardiotocography showed no clear difference in perinatal mortality rate (fetal and neonatal deaths excluding lethal… compared with intermittent auscultation (low‐risk women) (moderate certainty).

1 finding from 1 review

Admission cardiotocography vs intermittent auscultation

Incidence of continuous electronic fetal monitoring during labour · Low risk pregnant women. All of the women were in labour.

Admission cardiotocography may leads to higher incidence of continuous electronic fetal monitoring during labour compared with intermittent auscultation (low‐risk women) (low certainty).

1 finding from 1 review

Admission cardiotocography vs intermittent auscultation

Incidence and severity of hypoxic ischaemic encephalopathy (incidence only reported) · Low risk pregnant women. All of the women were in labour.

It is very uncertain whether admission cardiotocography changes incidence and severity of hypoxic ischaemic encephalopathy… compared with intermittent auscultation (low‐risk women) (very low certainty).

1 finding from 1 review

Admission cardiotocography vs intermittent auscultation

Neonatal seizures · Low risk pregnant women. All of the women were in labour.

Admission cardiotocography showed no clear difference in incidence of seizures in the neonatal period compared with intermittent auscultation (low‐risk women) (low certainty).

1 finding from 1 review