Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,788 questions · 1,849 findings · 336 reviews

No studies found 245 · 13.3%GRADE not reported 126 · 6.8%Very low 612 · 33.1%Low 512 · 27.7%Moderate 305 · 16.5%High 49 · 2.7%

Single‐fraction radiotherapy (8 Gy) vs short‐course radiotherapy (16 Gy

Urinary continence One month after radiation · adults with metastatic extradural spinal cord compression (poor prognosis with visceral metastasis, and no spinal instability or bony…

Single‐fraction radiotherapy (8 Gy) showed no clear difference in urinary continence One month after radiation compared with short‐course radiotherapy (16 Gy (moderate certainty).

1 finding from 1 review

Single‐fraction radiotherapy (8 Gy) vs short‐course radiotherapy (16 Gy

Local recurrence · adults with metastatic extradural spinal cord compression (poor prognosis with visceral metastasis, and no spinal instability or bony…

Single‐fraction radiotherapy (8 Gy) showed no clear difference in local recurrence MRI: compared with short‐course radiotherapy (16 Gy (low certainty).

1 finding from 1 review

Single‐fraction radiotherapy (8 Gy) vs short‐course radiotherapy (16 Gy

Adverse events Grade 3 oesophagitis, diarrhoea and nausea · adults with metastatic extradural spinal cord compression (poor prognosis with visceral metastasis, and no spinal instability or bony…

Single‐fraction radiotherapy (8 Gy) showed no clear difference in adverse events Grade 3 oesophagitis, diarrhoea and nausea compared with short‐course radiotherapy (16 Gy (moderate certainty).

1 finding from 1 review

Split‐course radiotherapy (8 fractions, 30 Gy) vs short‐course radiotherapy (16 Gy

Ambulation · adults with metastatic extradural spinal cord compression (poor prognosis, no spinal instability or bony impingement of cord)

Split‐course radiotherapy (8 fractions, 30 Gy) showed no clear difference in ambulation One month after treatment compared with short‐course radiotherapy (2 fractions, 16 Gy) (moderate certainty).

1 finding from 1 review

Long protocol vs short protocol

Ongoing pregnancy / live birth rate per woman · women undergoing pituitary suppression in assisted reproduction

Long protocol showed no clear difference in live birth or ongoing pregnancies per woman randomised compared with short protocol (low certainty).

1 finding from 1 review

Long‐stored ('older') PRBC (≥ 21 days of storage) vs short‐stored (fresh) PRBC (< 21 days of storage)

Death from any cause · patients requiring blood transfusion (children with malaria and adults with a traumatic injury)

It is very uncertain whether long‐stored ('older') PRBC (≥ 21 days of storage) changes death from any cause compared with short‐stored (fresh) PRBC (< 21 days of storage) (very low certainty).

1 finding from 1 review

Long‐stored ('older') PRBC (≥ 21 days of storage) vs short‐stored (fresh) PRBC (< 21 days of storage)

Transfusion‐related acute lung injury ‐ not measured · patients requiring blood transfusion (children with malaria and adults with a traumatic injury)

The review found no eligible studies for this question.

1 finding from 1 review