What do systematic reviews say?

Bisphosphonates vs placebo/observation

• Bisphosphonates and other bone agents for breast cancer 2017 · Cochrane Headline outcomes only
  no estimate extracted
  9 studies · 13242 participants
  High

Chemotherapy alone vs same chemotherapy plus radiotherapy

Chemotherapy alone may leads to lower secondary malignant neoplasms compared with same chemotherapy plus radiotherapy (low certainty).

• Optimisation of chemotherapy and radiotherapy for untreated Hodgkin lymphoma patients with respect to second malignant… 2017 · Cochrane Headline outcomes only
  OR 0.43 [0.23, 0.82]
  3 studies · 1011 participants
  Low

Fewer vs more courses of chemotherapy (with or without radiotherapy

Fewer showed no clear difference in secondary malignant neoplasms compared with more courses of chemotherapy (with or without radiotherapy (moderate certainty).

• Optimisation of chemotherapy and radiotherapy for untreated Hodgkin lymphoma patients with respect to second malignant… 2017 · Cochrane Headline outcomes only
  OR 1.1 [0.74, 1.62]
  3 studies · 2403 participants
  Moderate

Fewer vs more courses of chemotherapy (with or without radiotherapy

Fewer showed no clear difference in death compared with more courses of chemotherapy (with or without radiotherapy (high certainty).

• Optimisation of chemotherapy and radiotherapy for untreated Hodgkin lymphoma patients with respect to second malignant… 2017 · Cochrane Headline outcomes only
  HR 0.99 [0.73, 1.34]
  3 studies · 2403 participants
  High

Fewer vs more courses of chemotherapy (with or without radiotherapy

Fewer showed no clear difference in progression/relapse compared with more courses of chemotherapy (with or without radiotherapy (high certainty).

• Optimisation of chemotherapy and radiotherapy for untreated Hodgkin lymphoma patients with respect to second malignant… 2017 · Cochrane Headline outcomes only
  HR 1.15 [0.91, 1.45]
  3 studies · 2403 participants
  High

Chemotherapy alone vs same chemotherapy plus radiotherapy

Chemotherapy alone showed no clear difference in death compared with same chemotherapy plus radiotherapy (moderate certainty).

• Optimisation of chemotherapy and radiotherapy for untreated Hodgkin lymphoma patients with respect to second malignant… 2017 · Cochrane Headline outcomes only
  HR 0.71 [0.46, 1.11]
  3 studies · 1011 participants
  Moderate

Chemotherapy alone vs same chemotherapy plus radiotherapy

Chemotherapy alone showed no clear difference in progression/relapse compared with same chemotherapy plus radiotherapy (moderate certainty).

• Optimisation of chemotherapy and radiotherapy for untreated Hodgkin lymphoma patients with respect to second malignant… 2017 · Cochrane Headline outcomes only
  HR 1.31 [0.99, 1.73]
  3 studies · 1011 participants
  Moderate

Chemotherapy plus involved‐field radiation vs same chemotherapy plus extended‐field radiation

Chemotherapy plus involved‐field radiation showed no clear difference in secondary malignant neoplasms compared with same chemotherapy plus extended‐field radiation (low certainty).

• Optimisation of chemotherapy and radiotherapy for untreated Hodgkin lymphoma patients with respect to second malignant… 2017 · Cochrane Headline outcomes only
  OR 0.86 [0.64, 1.16]
  4 studies · 2397 participants
  Low

Chemotherapy plus involved‐field radiation vs same chemotherapy plus extended‐field radiation

Chemotherapy plus involved‐field radiation showed no clear difference in death compared with same chemotherapy plus extended‐field radiation (high certainty).

• Optimisation of chemotherapy and radiotherapy for untreated Hodgkin lymphoma patients with respect to second malignant… 2017 · Cochrane Headline outcomes only
  HR 0.89 [0.7, 1.12]
  4 studies · 2397 participants
  High

Chemotherapy plus involved‐field radiation vs same chemotherapy plus extended‐field radiation

Chemotherapy plus involved‐field radiation showed no clear difference in progression/relapse compared with same chemotherapy plus extended‐field radiation (high certainty).

• Optimisation of chemotherapy and radiotherapy for untreated Hodgkin lymphoma patients with respect to second malignant… 2017 · Cochrane Headline outcomes only
  HR 0.99 [0.81, 1.21]
  4 studies · 2397 participants
  High

Chemotherapy plus lower‐dose radiation vs same chemotherapy plus higher‐dose radiation

Chemotherapy plus lower‐dose radiation showed no clear difference in secondary malignant neoplasms compared with same chemotherapy plus higher‐dose radiation (low certainty).

• Optimisation of chemotherapy and radiotherapy for untreated Hodgkin lymphoma patients with respect to second malignant… 2017 · Cochrane Headline outcomes only
  OR 1.03 [0.71, 1.5]
  3 studies · 2962 participants
  Low

Chemotherapy plus lower‐dose radiation vs same chemotherapy plus higher‐dose radiation

Chemotherapy plus lower‐dose radiation showed no clear difference in death compared with same chemotherapy plus higher‐dose radiation (high certainty).

• Optimisation of chemotherapy and radiotherapy for untreated Hodgkin lymphoma patients with respect to second malignant… 2017 · Cochrane Headline outcomes only
  HR 0.91 [0.65, 1.28]
  3 studies · 2962 participants
  High

Chemotherapy plus lower‐dose radiation vs same chemotherapy plus higher‐dose radiation

Chemotherapy plus lower‐dose radiation showed no clear difference in progression/relapse compared with same chemotherapy plus higher‐dose radiation (high certainty).

• Optimisation of chemotherapy and radiotherapy for untreated Hodgkin lymphoma patients with respect to second malignant… 2017 · Cochrane Headline outcomes only
  HR 1.2 [0.97, 1.48]
  3 studies · 2962 participants
  High

0.9% silicon tetrafluoride (SiF4) vs Not specified

One trial found professionally applied silicon tetrafluoride did not remineralise white spot lesions; ungraded.

• Caries remineralisation and arresting effect in children by professionally applied fluoride treatment - a systematic… 2016 All outcomes

  Children in clinical dental settings
  One study found that silicon tetrafluoride could not remineralise white spot lesions.
  1 study
  GRADE not reported

Intervention not reported

The review found no eligible studies for this question.

• Culture media for human pre‐implantation embryos in assisted reproductive technology cycles 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

It is very uncertain whether the intervention changes late embryo transfer ‐ GM501 (specific) versus Sydney IVF (other) (very low certainty).

• Culture media for human pre‐implantation embryos in assisted reproductive technology cycles 2015 · Cochrane Headline outcomes only
  OR 0.67 [0.03, 14.03]
  1 study · 12 participants
  Very low

Intervention not reported

It is very uncertain whether the intervention changes late embryo transfer ‐ G2 (specific) versus Universal IVF (other) (very low certainty).

• Culture media for human pre‐implantation embryos in assisted reproductive technology cycles 2015 · Cochrane Headline outcomes only
  OR 1.92 [0.44, 8.31]
  1 study · 47 participants
  Very low

Intervention not reported

It is very uncertain whether the intervention changes late embryo transfer ‐ ECM/Multiblast (specific) versus Global (other) (very low certainty).

• Culture media for human pre‐implantation embryos in assisted reproductive technology cycles 2015 · Cochrane Headline outcomes only
  OR 0.5 [0.2, 1.26]
  1 study · 79 participants
  Very low

Intervention not reported

It is very uncertain whether the intervention changes ascitis (very low certainty).

• Corticosteroids for dengue infection 2014 · Cochrane Headline outcomes only
  RR 0.12 [0.01, 2.13]
  1 study · 178 participants
  Very low

Intervention not reported

It is very uncertain whether the intervention changes ICU admission (very low certainty).

• Corticosteroids for dengue infection 2014 · Cochrane Headline outcomes only
  RR 0.88 [0.38, 1.99]
  2 studies · 286 participants
  Very low