Specificity for detection of enamel caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
1 finding from 1 review
Diagnostic accuracy on surfaces with pit and fissure sealants · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
The review found no eligible studies for this question.
1 finding from 1 review
Sensitivity for detection of enamel caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
1 finding from 1 review
Caries incidence of first permanent molars (FPMs) · Generally healthy children aged 6 to 9 years with at least one fully erupted first permanent molar with deep fissures or early enamel…
After excluding the high-risk-of-bias study (Bravo 1996), fluoride varnish and fissure sealant did not differ in caries incidence of FPMs and heterogeneity fell to 0% (RR 1.05, 95% CI 0.91 to 1.22; 5 RCTs; ungraded).
3 findings from 1 review
Caries incidence (proportion of enrolled children developing dentin caries, ICDAS 4-6) · Generally healthy children aged 6 to 9 years with at least one fully erupted first permanent molar with deep fissures or early enamel…
Fluoride varnish and fissure sealant did not differ significantly in the proportion of children developing caries at 2 to 3 years (RR 1.12, 95% CI 0.60 to 2.09; 2 RCTs; ungraded).
1 finding from 1 review
Caries incidence of occlusal surfaces of first permanent molars · Generally healthy children aged 6 to 9 years with at least one fully erupted first permanent molar with deep fissures or early enamel…
After excluding Bravo 1996, occlusal caries incidence slightly favored fluoride varnish but was not significant, with heterogeneity falling to 0% (RR 0.98, 95% CI 0.82 to 1.16; 3 RCTs; ungraded).
2 findings from 1 review
Disability due to FAP progression Not measured · people with early‐stage TTR‐FAP
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Severity of peripheral neuropathy (expressed as the change in NIS‐LL) Scale from: 0 (normal) to 88 (total impairment) · people with early‐stage TTR‐FAP
1 finding from 1 review
QoL · people with early‐stage TTR‐FAP
1 finding from 1 review
Has died · people with early‐stage TTR‐FAP
It is very uncertain whether tafamidis changes number of participants who died during the trial compared with placebo (very low certainty).
1 finding from 1 review
Withdrawals due to adverse events · people with early‐stage TTR‐FAP
It is very uncertain whether tafamidis changes number of dropouts due to adverse events compared with placebo (very low certainty).
1 finding from 1 review
Number of participants experiencing at least one severe adverse event · people with early‐stage TTR‐FAP
It is very uncertain whether tafamidis changes number of participants experiencing at least one severe adverse event compared with placebo (very low certainty).
1 finding from 1 review
Primary outcomes · infants at risk for, or having early symptoms consistent with, opioid withdrawal
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
– Modifying environmental stimulation · infants at risk for, or having early symptoms consistent with, opioid withdrawal
1 finding from 1 review
– Feeding practices · infants at risk for, or having early symptoms consistent with, opioid withdrawal
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
– Support of the mother‐infant dyad · infants at risk for, or having early symptoms consistent with, opioid withdrawal
1 finding from 1 review
Admission to NICU (primary outcome)№ of participants: 204(1 RCT) · infants at risk for, or having early symptoms consistent with, opioid withdrawal
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Increment of occlusal DMFS (decayed, missing, filled surfaces) of FPMs · Generally healthy children aged 6 to 9 years with at least one fully erupted first permanent molar with deep fissures or early enamel…
Fluoride varnish and fissure sealant did not differ significantly in occlusal DMFS increment of FPMs (MD 0.13, 95% CI -0.09 to 0.34; 3 RCTs; ungraded).
2 findings from 1 review
Dental caries · Children aged 5-7 years (early school-age)
In early school-age children (5-7 y) from weakly contaminated areas, individual cross-sectional studies reported mostly higher but inconsistent DMFT/dmft in exposed vs non-exposed children; the review did not pool the data and drew no firm conclusion (ungraded).
4 findings from 1 review
A systematic review of the caries prevalence among children living in Chernobyl fallout countries. 2019 All outcomesChernobyl fallout areas, Eastern Europe (Ukraine, Belarus, Russian Federation) · weak contamination
WMD 0.45 [0.32, 0.58]
1 study · 117 participants
GRADE not reported
A systematic review of the caries prevalence among children living in Chernobyl fallout countries. 2019 All outcomesChernobyl fallout areas, Eastern Europe (Ukraine, Belarus, Russian Federation) · weak contamination
WMD 6.51 [6.11, 6.91]
1 study · 27 participants
GRADE not reported
A systematic review of the caries prevalence among children living in Chernobyl fallout countries. 2019 All outcomesChernobyl fallout areas, Eastern Europe (Ukraine, Belarus, Russian Federation) · weak contamination
WMD 4.65 [4.50, 4.80]
1 study · 165 participants
GRADE not reported
Show 1 more finding
Enamel surface microhardness · Extracted human teeth with early/artificial enamel lesions (in vitro)
In vitro, CPP-ACP increased Vickers microhardness versus control (SMD 1.19, 95% CI 0.72 to 1.66; ungraded).
3 findings from 1 review
SMD 1.19 [0.72, 1.66]
5 studies · 106 participants
GRADE not reported
SMD 2.07 [1.24, 2.89]
8 studies · 170 participants
GRADE not reported
SMD 3.52 [2.68, 4.36]
3 studies · 64 participants
GRADE not reported