CPP-ACP vs No active treatment (control): Enamel surface microhardness
In vitro, CPP-ACP increased Vickers microhardness versus control (SMD 1.19, 95% CI 0.72 to 1.66; ungraded).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
CPP-ACP agent (e.g., GC Tooth Mousse, GC Tooth Mousse Plus) vs Control (no treatment / negative control) Enamel surface microhardness · Extracted human teeth with early/artificial enamel lesions (in vitro) · 6 hours to 30 days, In vitro (extracted human teeth), Vickers microhardness In vitro, CPP-ACP increased Vickers microhardness versus control (SMD 1.19, 95% CI 0.72 to 1.66; ungraded). Evaluation of the efficacy of casein phosphopeptide-amorphous calcium phosphate on remineralization of white… (2019) All outcomes | SMD 1.19 [0.72, 1.66] | 5 studies · 106 participants | GRADE not reported |
CPP-ACP agent (e.g., GC Tooth Mousse, GC Tooth Mousse Plus, MI Paste Plus) vs Control (no treatment / negative control) Enamel surface microhardness · Extracted human teeth with early/artificial enamel lesions (in vitro) · 6 hours to 30 days, In vitro (extracted human teeth) In vitro, CPP-ACP significantly increased enamel surface microhardness versus control (SMD 2.07, 95% CI 1.24 to 2.89; ungraded). Evaluation of the efficacy of casein phosphopeptide-amorphous calcium phosphate on remineralization of white… (2019) All outcomes | SMD 2.07 [1.24, 2.89] | 8 studies · 170 participants | GRADE not reported |
CPP-ACP agent (e.g., GC Tooth Mousse, MI Paste Plus) vs Control (no treatment / negative control) Enamel surface microhardness · Extracted human teeth with early/artificial enamel lesions (in vitro) · 5 to 7 days, In vitro (extracted human teeth), Knoop microhardness In vitro, CPP-ACP increased Knoop microhardness versus control (SMD 3.52, 95% CI 2.68 to 4.36; ungraded). Evaluation of the efficacy of casein phosphopeptide-amorphous calcium phosphate on remineralization of white… (2019) All outcomes | SMD 3.52 [2.68, 4.36] | 3 studies · 64 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Evaluation of the efficacy of casein phosphopeptide-amorphous calcium phosphate on remineralization of white spot lesions in vitro and… 2019 All outcomes | May 20, 2019 | 12 | Critically Low / Critically Low |
Studies behind the findings
The primary studies the full-text reviews tie to this outcome. Reviews with headline outcomes only do not list them here.
- Assessment of Enamel Remineralisation After Treatment with Four Different Remineralising Agents: A Scanning Electron Microscopy (SEM) Study. · 2017 · included by 1 of these review
- Effect of Three Different Pastes on Remineralization of Initial Enamel Lesion: An in Vitro Study · 2015 · included by 1 of these review
- Effect of various remineralising agents on human eroded enamel of primary teeth · 2013 · included by 1 of these review
- Protective effect of calcium nanophosphate and CPP-ACP agents on enamel erosion · 2013 · included by 1 of these review
- Carvalho 2014 · included by 1 of these review
- Kargul 2012 · included by 1 of these review
- Rirattanapong 2012 · included by 1 of these review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.