Initiation of white spot lesions (WSL), visual-tactile assessment · Patients of any age (11-40 years) receiving comprehensive/fixed orthodontic treatment with fixed appliances
The additional use of a sealant probably reduces the initiation of white spot lesions during fixed orthodontic treatment compared with no sealant (RR 0.70), but the certainty of evidence is very low.
1 finding from 1 review
Iron deficiency anaemia · Preschool children (<6 years)
Children with early childhood caries were more likely to have iron-deficiency anemia than caries-free children (OR 2.74, 95% CI 2.41 to 3.11); ungraded.
1 finding from 1 review
Maximal mouth opening (interincisal distance) · Adults (general and hospital populations assessed in case-control studies)
Systemic sclerosis patients have significantly reduced mouth opening compared with controls (SMD -1.06); certainty ungraded.
1 finding from 1 review
Serum ferritin (ng/mL) · Preschool children (<6 years)
Serum ferritin levels did not differ significantly between children with ECC and caries-free children (mean difference -5.80, 95% CI -11.97 to 0.37); ungraded.
1 finding from 1 review
White spot lesions assessed by laser fluorescence (DIAGNOdent) · Patients of any age (11-40 years) receiving comprehensive/fixed orthodontic treatment with fixed appliances
White spot lesions were also measured by laser fluorescence in 3 fluoride-vs-non-fluoride studies, but no meta-analysis was possible due to incompatible reporting.
1 finding from 1 review
Dental caries · Individuals in East Africa assessed for dental caries
Frequent carbohydrate intake was associated with significantly higher odds of dental caries (OR 1.575, 95% CI 1.13 to 3.051); certainty not graded.
1 finding from 1 review
Number of teeth · Adults (general and hospital populations assessed in case-control studies)
No statistically significant difference in number of teeth between SSc patients and controls (SMD -0.95, CI includes 0); certainty ungraded.
1 finding from 1 review
Intervention not reported
Dental caries prevalence · General population (children and adults) in East Africa
Caries prevalence in mixed dentition (6-12 years) was 41.3% (95% CI 33.5 to 49.2); certainty not graded.
1 finding from 1 review
Intervention not reported
Mean DMFT (decayed, missing, filled permanent teeth) · Individuals with permanent dentition in East Africa
The pooled mean DMFT (permanent dentition) in East Africa was 1.941 (95% CI 1.561 to 2.322); certainty not graded.
1 finding from 1 review
Dental caries · Individuals in East Africa assessed for dental caries
Females had significantly higher odds of dental caries than males (OR 1.333, 95% CI 1.129 to 1.575); certainty not graded.
1 finding from 1 review
All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies
In prospective cohorts, edentulous adults (0 teeth) had a higher cumulative incidence of all-cause mortality than adults with 20-32 teeth (RR 2.27, 95% CI 1.82 to 2.83; 8 cohort studies, I2=94%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).
1 finding from 1 review
Mean number of missing teeth in OC cases vs controls · Adults (general and hospital populations assessed in case-control studies)
No statistically significant difference in number of missing teeth between SSc patients and controls (SMD 0.55, CI includes 0); certainty ungraded.
1 finding from 1 review
Intervention not reported
Dental caries prevalence
1 finding from 1 review
Intervention not reported
Dental caries prevalence
1 finding from 1 review
Intervention not reported
Dental caries prevalence
1 finding from 1 review
Mean corpuscular volume (MCV) · Preschool children (<6 years)
Mean corpuscular volume was significantly lower in children with ECC than in caries-free children (mean difference -3.72, 95% CI -6.65 to -0.79); ungraded.
1 finding from 1 review
Intervention not reported
Initiation of white spot lesions (WSL), visual-tactile assessment
The intervention showed no clear difference in initiation of white spot lesions (WSL), visual-tactile assessment; GRADE not reported.
1 finding from 1 review
RR 0.83 [0.67, 1.04]
Studies not reported
GRADE not reported
Dental caries · Individuals in East Africa assessed for dental caries
Residency was not significantly associated with dental caries (OR 0.962, 95% CI 0.595 to 1.554); certainty not graded.
1 finding from 1 review
Lesion area (decalcification area, pixels) · Adults undergoing orthodontic treatment
A single study reported a larger decalcification lesion area with aligners versus fixed appliances in adults at 3 months (MD 80.50 pixels, 95% CI 60.52 to 100.48; ungraded).
1 finding from 1 review
MD 80.50 [60.52, 100.48]
1 study
GRADE not reported
Initiation of white spot lesions (WSL), visual-tactile assessment · Patients of any age (11-40 years) receiving comprehensive/fixed orthodontic treatment with fixed appliances
Fluoride-releasing coating materials do not appear to reduce WSL initiation more than non-fluoride coatings (RR 0.84, not significant); certainty of evidence is very low.
1 finding from 1 review