Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

246 questions · 262 findings · 25 reviews · Headline outcomes only

No studies found 40 · 15.3%GRADE not reported 11 · 4.2%Very low 78 · 29.8%Low 74 · 28.2%Moderate 50 · 19.1%High 9 · 3.4%

Tacrolimus 0.1% vs vehicle

Primary: participant‐rated good/excellent control of symptoms Not measured · people with moderate to severe nickel sulphate‐induced allergic contact dermatitis based on clinical history (hand eczema) and proven by…

The review found no eligible studies for this question.

1 finding from 1 review

Tacrolimus 0.1% vs vehicle

Primary: adverse events ‐ burning/itching at application site · people with moderate to severe nickel sulphate‐induced allergic contact dermatitis based on clinical history (hand eczema) and proven by…

Topical calcineurin inhibitors: tacrolimus 0.1% ointment showed no clear difference in primary: adverse events ‐ burning/itching at application site compared with vehicle (moderate certainty).

1 finding from 1 review

Tacrolimus 0.1% vs vehicle

Secondary: investigator‐rated reduction in severity ‐ Not measured · people with moderate to severe nickel sulphate‐induced allergic contact dermatitis based on clinical history (hand eczema) and proven by…

The review found no eligible studies for this question.

1 finding from 1 review

Strong steroid (class III or IV) vs mild steroid (class I or II)

Total clearance (at 4 weeks or less) Investigator's assessment · patients with seborrhoeic dermatitis

Strong steroid (class III or IV) showed no clear difference in total clearance (at 4 weeks or less) Investigator's assessment compared with mild steroid (class I or II) (moderate certainty).

1 finding from 1 review

Strong steroid (class III or IV) vs mild steroid (class I or II)

Total clearance (more than 4 weeks) Investigator's assessment · patients with seborrhoeic dermatitis

Strong steroid (class III or IV) may leads to lower total clearance (more than 4 weeks) Investigator's assessment compared with mild steroid (class I or II) (low certainty).

1 finding from 1 review