Corticosteroids vs placebo
- Corticosteroids as standalone or add‐on treatment for sore throat 2020 · Cochrane Headline outcomes onlyno estimate extracted6 studies · 695 participantsModerate
Corticosteroids showed no clear difference in adverse events compared with placebo (moderate certainty).
Corticosteroids showed no clear difference in recurrence/relapse rates compared with placebo (moderate certainty).
Corticosteroids probably leads to lower 28‐Day all‐cause mortalitya compared with placebo or usual care (moderate certainty).
Corticosteroids showed no clear difference in long‐term mortalityc compared with placebo or usual care (low certainty).
Corticosteroids probably leads to lower hospital mortality compared with placebo or usual care (moderate certainty).
Corticosteroids showed no clear difference in number of participants with adverse events ‐ superinfection (up to… compared with placebo or usual care (moderate certainty).
Corticosteroids leads to higher number of participants with adverse events ‐ muscle weakness (up to… compared with placebo or usual care (high certainty).
Corticosteroids probably leads to lower mortality ‐ adults compared with control (moderate certainty).
Corticosteroids probably leads to lower mortality ‐ adults ‐ severe CAP compared with control (moderate certainty).
Corticosteroids showed no clear difference in mortality ‐ adults ‐ non‐severe CAP compared with control (moderate certainty).
Corticosteroids probably leads to lower early clinical failure ‐ adults compared with control (moderate certainty).
Corticosteroids leads to lower early clinical failure ‐ adults ‐ severe CAP compared with control (high certainty).
Corticosteroids leads to lower early clinical failure ‐ adults ‐ non‐severe CAP compared with control (high certainty).
Corticosteroids leads to lower early clinical failure ‐ children compared with control (high certainty).
Corticosteroids leads to lower incomplete recovery ≥ 6 months after randomisation House‐Brackmann… compared with placebo or no treatment (high certainty).