Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,539 questions · 2,602 findings · 424 reviews · Headline outcomes only

No studies found 572 · 22%GRADE not reported 189 · 7.3%Very low 527 · 20.3%Low 685 · 26.3%Moderate 514 · 19.8%High 115 · 4.4%

Long‐acting beta2‐agonist plus tiotropium vs tiotropium

Mortality (all cause) · addition to tiotropium versus either tiotropium or LABA alone for chronic obstructive pulmonary disease

Long‐acting beta2‐agonist plus tiotropium showed no clear difference in mortality (all cause) compared with tiotropium alone (low certainty).

1 finding from 1 review

Supervised dosing with a long‐acting medication vs unsupervised consumption

Retention [ · patients with opioid dependence

Supervised dosing with a long‐acting medication showed no clear difference in retention ‐ retention at the end of treatment (number of participants) compared with unsupervised consumption (low certainty).

2 findings from 1 review

Supervised dosing with a long‐acting medication vs unsupervised consumption

Adverse serious events (any) (number of participants) · patients with opioid dependence

It is very uncertain whether supervised dosing with a long‐acting medication changes adverse serious events (any) (number of participants) compared with unsupervised consumption (very low certainty).

1 finding from 1 review

Long‐stored ('older') PRBC (≥ 21 days of storage) vs short‐stored (fresh) PRBC (< 21 days of storage)

Death from any cause · patients requiring blood transfusion (children with malaria and adults with a traumatic injury)

It is very uncertain whether long‐stored ('older') PRBC (≥ 21 days of storage) changes death from any cause compared with short‐stored (fresh) PRBC (< 21 days of storage) (very low certainty).

1 finding from 1 review

Long‐stored ('older') PRBC (≥ 21 days of storage) vs short‐stored (fresh) PRBC (< 21 days of storage)

Transfusion‐related acute lung injury ‐ not measured · patients requiring blood transfusion (children with malaria and adults with a traumatic injury)

The review found no eligible studies for this question.

1 finding from 1 review

Long protocol vs short protocol

Ongoing pregnancy / live birth rate per woman · women undergoing pituitary suppression in assisted reproduction

Long protocol showed no clear difference in live birth or ongoing pregnancies per woman randomised compared with short protocol (low certainty).

1 finding from 1 review