Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

234 questions · 236 findings · 33 reviews · Pregnancy and Childbirth

No studies found 20 · 8.5%GRADE not reported 12 · 5.1%Very low 63 · 26.7%Low 82 · 34.7%Moderate 40 · 16.9%High 19 · 8.1%

NSAIDs vs placebo

Need for additional analgesia (6 hours after administration) · women with perineal pain in the early postpartum period

It is very uncertain whether NSAID changes need for additional analgesia (6 hours after administration) compared with placebo (very low certainty).

1 finding from 1 review

NSAID (single administration, any dose) vs paracetamol

Relief of pain · women with perineal pain in the early postpartum period

NSAID (single administration, any dose) may leads to higher adequate pain relief (4 hours after administration) compared with paracetamol (low certainty).

2 findings from 1 review

Aspirin vs placebo

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · women with perineal pain in the early postpartum period

Aspirin may leads to higher adequate pain relief as reported by the woman (4 to 8 hours) compared with placebo (low certainty).

1 finding from 1 review

Aspirin vs placebo

Need for additional pain relief (4 to 8 hours) · women with perineal pain in the early postpartum period

It is very uncertain whether aspirin changes need for additional pain relief (4 to 8 hours) compared with placebo (very low certainty).

1 finding from 1 review