Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,954 questions · 2,335 findings · 149 reviews · All outcomes

No studies found 436 · 18.7%GRADE not reported 1,370 · 58.7%Very low 254 · 10.9%Low 173 · 7.4%Moderate 80 · 3.4%High 22 · 0.9%

Non-syndromic cleft lip and palate (CLP) status and its oral microbiota (exposure/grouping) vs Children and adolescents aged 0-18 years without CLP (controls)

Periodontal conditions (gingival inflammation, bleeding on probing, probing depth, clinical attachment loss) · Children and adolescents aged 0-18 years with non-syndromic cleft lip and palate (CLP)

Narrative synthesis of 6 studies suggests children/adolescents with CLP have poorer periodontal status (higher gingival and plaque indices, deeper probing, more bleeding and attachment loss) and harbor periodontopathogens; no pooled estimate and the evidence is ungraded.

1 finding from 1 review

Cervical pull headgear vs Minor interceptive procedures (control)

Amount of crowding (lower incisor crowding) at 10 weeks · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth

It is very uncertain whether cervical pull headgear changes amount of crowding (lower incisor crowding) at 2 years compared with minor interceptive procedures (control) (very low certainty).

1 finding from 1 review

Cervical pull headgear vs Minor interceptive procedures (control)

Position of the incisors (upper incisor inclination) · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth

Cervical pull headgear led to higher upper incisors to maxilla at 2 years compared with minor interceptive procedures (control); GRADE not reported.

1 finding from 1 review

Extraction of third molars (wisdom teeth) vs No active treatment (control)

Amount of crowding · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth

It is very uncertain whether extraction of third molars (wisdom teeth) changes amount of crowding (Little's Irregularity Index, change) at 5 years compared with no active treatment (control) (very low certainty).

1 finding from 1 review

Extraction of lower deciduous canines vs No active treatment (control)

Amount of crowding · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth

It is very uncertain whether extraction of lower deciduous canines changes amount of crowding (lower incisor crowding, change) at 1-2 years compared with no active treatment (control) (very low certainty).

1 finding from 1 review

Cervical pull headgear vs Minor interceptive procedures (control)

Lower incisors to mandible (relationship of lower front teeth to the mandible) · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth

Cervical pull headgear showed no clear difference in lower incisors to mandible at 2 years compared with minor interceptive procedures (control); GRADE not reported.

1 finding from 1 review

Clinical examination with risk-based recall vs Clinical examination with 24-month recall

Periodontal disease: gingival bleeding (percentage of sites) · Dentate adults (aged 18 years and older) receiving dental check-ups in UK general dental practices (regular attenders)

Clinical examination with risk-based recall showed no clear difference in periodontal disease: gingival bleeding (percentage of sites) compared with clinical examination with 24-month recall (high certainty).

1 finding from 1 review

Clinical examination with risk-based recall vs Clinical examination with 6-month recall

Periodontal disease: gingival bleeding (percentage of sites) · Dentate adults (aged 18 years and older) receiving dental check-ups in UK general dental practices (regular attenders)

Clinical examination with risk-based recall showed no clear difference in periodontal disease: gingival bleeding (percentage of sites) compared with clinical examination with 6-month recall (high certainty).

1 finding from 1 review

Clinical examination with 24-month recall vs Clinical examination with 6-month recall

Periodontal disease: gingival bleeding (percentage of sites) · Dentate adults (aged 18 years and older) receiving dental check-ups in UK general dental practices (regular attenders)

Clinical examination with 24-month recall showed no clear difference in periodontal disease: gingival bleeding (percentage of sites) compared with clinical examination with 6-month recall (moderate certainty).

1 finding from 1 review

Motivational interview plus oral health education vs Oral health education

Self regulation: Average score (Treatment Self Regulation Questionnaire, high score = good) · People with serious mental illness (all included participants had schizophrenia); majority aged 18 to 65 years per NIMH 1987, or with…

Motivational interview plus oral health education showed no clear difference in self regulation: Average score (Treatment Self Regulation… compared with oral health education; GRADE not reported.

3 findings from 1 review

Motivational interview plus oral health education vs Oral health education

Oral health knowledge (1-9 scale) · People with serious mental illness (all included participants had schizophrenia); majority aged 18 to 65 years per NIMH 1987, or with…

Motivational interview plus oral health education led to higher knowledge: Average score (Oral Health Knowledge Questionnaire, high… compared with oral health education; GRADE not reported.

1 finding from 1 review

Intraoral distalising appliance vs Headgear (extraoral appliance)

Adverse effects (headgear injuries, gum health, tooth damage/decay, root resorption) · Children and adolescents (aged 16 years or less at the start of treatment) undergoing orthodontic treatment to distalise upper first…

The review found no eligible studies for this question.

1 finding from 1 review

Visual screening (oral visual inspection) by trained health workers vs No screening

Stage at diagnosis (early-stage detection) · Apparently healthy adults aged 35 years or older (general population), living in 13 clusters in rural areas of Trivandrum city, Kerala,…

Visual screening (oral visual inspection) by trained health workers led to lower stage at diagnosis (early-stage detection) compared with no screening; GRADE not reported.

2 findings from 1 review

Intraoral distalising appliance vs Another (different) intraoral distalising appliance

Adverse effects (headgear injuries, gum health, tooth damage/decay, root resorption) · Children and adolescents (aged 16 years or less at the start of treatment) undergoing orthodontic treatment to distalise upper first…

The review found no eligible studies for this question.

1 finding from 1 review

Orthodontic distalising appliance (intraoral or extraoral) vs no intervention

Adverse effects (headgear injuries, gum health, tooth damage/decay, root resorption) · Children and adolescents (aged 16 years or less at the start of treatment) undergoing orthodontic treatment to distalise upper first…

The review found no eligible studies for this question.

1 finding from 1 review

HAART regimen + topical treatment vs HAART alone

Adverse effects of long‐term use of available topical agents · HIV‐infected adults (> 13 years of age, per CDC) with one or more painful intraoral aphthous ulcers

The review found no eligible studies for this question.

1 finding from 1 review
  • No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6…
    0 studies
    No studies found

Individually designed, patient-centred preventive programme: dietary counselling (snacking timing, regular meals, fermentable carbohydrates) plus toothbrushing counselling, delivered by trained dental hygienists (a multi-intervention) vs Basic prevention offered as standard in public dental clinics

Caries increment on tooth surfaces (dmfs/DMFS) (prevented fraction) · Children aged 11 to 12 years with at least one active initial caries lesion, screened in a town in Finland
2 findings from 1 review