Event‐free survival · women with early poor prognosis breast cancer
High‐dose chemotherapy showed no clear difference in event‐free survival at 5‐year compared with chemotherapy without bone marrow transplant or stem cell rescue (high certainty).
1 finding from 1 review
Treatment‐related mortality · women with early poor prognosis breast cancer
High‐dose chemotherapy leads to higher treatment‐related mortality compared with chemotherapy without bone marrow transplant or stem cell rescue (high certainty).
1 finding from 1 review
Second cancers at 4 ‐ 9‐year median · women with early poor prognosis breast cancer
High‐dose chemotherapy showed no clear difference in second cancers at 4 ‐ 9‐year median compared with chemotherapy without bone marrow transplant or stem cell rescue (high certainty).
1 finding from 1 review
Local recurrence‐free survival · women treated with breast conserving therapy for early breast cancer
Hypofractionated radiation therapy showed no clear difference in local recurrence‐free survival (LR‐FS) at 10 years compared with conventionally fractionated radiation therapy (high certainty).
1 finding from 1 review
Cosmesis · women treated with breast conserving therapy for early breast cancer
Hypofractionated radiation therapy showed no clear difference in cosmesis compared with conventionally fractionated radiation therapy (high certainty).
1 finding from 1 review
Mortality at 10 years · women treated with breast conserving therapy for early breast cancer
Hypofractionated radiation therapy showed no clear difference in mortality at 10 years compared with conventionally fractionated radiation therapy (high certainty).
1 finding from 1 review
Late subcutaneous toxicity · women treated with breast conserving therapy for early breast cancer
Hypofractionated radiation therapy showed no clear difference in late subcutaneous toxicity compared with conventionally fractionated radiation therapy (high certainty).
1 finding from 1 review
Breast cancer‐specific survival · women treated with breast conserving therapy for early breast cancer
Hypofractionated radiation therapy showed no clear difference in breast cancer‐specific survival (BC‐SS) at 10 years compared with conventionally fractionated radiation therapy (high certainty).
1 finding from 1 review
Proportion of participants with relapse‐free survival at ≥ 12 months · women treated with breast conserving therapy for early breast cancer
Hypofractionated radiation therapy showed no clear difference in relapse‐free survival (RFS) at 10 years compared with conventionally fractionated radiation therapy (moderate certainty).
1 finding from 1 review
Mastectomy rate ‐ not measured · women treated with breast conserving therapy for early breast cancer
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
Death from all causes · patients with early stage cervical cancer
The intervention probably leads to lower death from all causes (moderate certainty).
1 finding from 1 review
Intervention not reported
Disease progression · patients with early stage cervical cancer
The intervention probably leads to lower disease progression (moderate certainty).
1 finding from 1 review
Intervention not reported
Grade 4 toxicity3 · patients with early stage cervical cancer
The intervention probably leads to higher grade 4 toxicity3 (moderate certainty).
1 finding from 1 review
Intervention not reported
Disease progression · patients with early stage cervical cancer
The intervention showed no clear difference in disease progression (low certainty).
1 finding from 1 review
Neurodevelopmental outcomes · Preterm infants requiring surgery for inguinal hernia in early infancy
1 finding from 1 review
Apnoea/bradycardia occurring 12‐24 hours following completion of operation · Preterm infants requiring surgery for inguinal hernia in early infancy
Regional (spinal, epidural, caudal) showed no clear difference in apnoea/bradycardia occurring 12‐24 hours following completion of… compared with general anaesthesia (moderate certainty).
1 finding from 1 review
Any oxygen desaturation occurring 12‐24 hours following completion of the operation · Preterm infants requiring surgery for inguinal hernia in early infancy
Regional (spinal, epidural, caudal) showed no clear difference in any oxygen desaturation occurring 12‐24 hours following completion… compared with general anaesthesia (moderate certainty).
1 finding from 1 review
Use of post‐operative respiratory support · Preterm infants requiring surgery for inguinal hernia in early infancy
Regional (spinal, epidural, caudal) showed no clear difference in use of post‐operative respiratory support compared with general anaesthesia (low certainty).
1 finding from 1 review
Post‐operative apnoea with preoperative sedatives excluded · Preterm infants requiring surgery for inguinal hernia in early infancy
Regional (spinal, epidural, caudal) probably leads to lower post‐operative apnoea with preoperative sedatives excluded compared with general anaesthesia (moderate certainty).
1 finding from 1 review
Anaesthetic agent failure · Preterm infants requiring surgery for inguinal hernia in early infancy
Regional (spinal, epidural, caudal) may leads to higher anaesthetic agent failure compared with general anaesthesia (low certainty).
1 finding from 1 review