Cochrane · systematic review · CD003860
Hypofractionated radiation therapy for early breast cancer
Hickey, BE, James, ML, Lehman, M, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
Breast CancerAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
6
No studies
1
Included studies
NR
No studies 1 · 14.3%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 1 · 14.3%High 5 · 71.4%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Hypofractionated radiation therapy compared to conventionally fractionated radiation therapy for women treated with breast conserving therapy for early breast cancer
Population: women treated with breast conserving therapy for early breast cancer
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Local recurrence‐free survival (LR‐FS) at 10 years Hypofractionated radiation therapy vs conventionally fractionated radiation therapy | HR 0.94 [0.77, 1.15] | 4 studies · 7095 participants | High |
Cosmesis Hypofractionated radiation therapy vs conventionally fractionated radiation therapy | RR 0.9 [0.81, 1.01] | 4 studies · 2103 participants | High |
Mortality at 10 years Hypofractionated radiation therapy vs conventionally fractionated radiation therapy | HR 0.91 [0.8, 1.03] | 3 studies · 5685 participants | High |
Late subcutaneous toxicity Hypofractionated radiation therapy vs conventionally fractionated radiation therapy | RR 0.93 [0.83, 1.05] | 4 studies · 5130 participants | High |
Breast cancer‐specific survival (BC‐SS) at 10 years Hypofractionated radiation therapy vs conventionally fractionated radiation therapy | HR 0.91 [0.78, 1.06] | 3 studies · 5685 participants | High |
Relapse‐free survival (RFS) at 10 years Hypofractionated radiation therapy vs conventionally fractionated radiation therapy | HR 0.93 [0.82, 1.05] | 3 studies · 5685 participants | Moderate Downgraded: inconsistency |
Mastectomy rate ‐ not measured Hypofractionated radiation therapy vs conventionally fractionated radiation therapy | no estimate extracted | NR | No studies |