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What do systematic reviews say?

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Evidence found and GRADE certainty

4,678 questions · 4,859 findings · 283 reviews

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No studies found 1,225 · 25.2%GRADE not reported 215 · 4.4%Very low 1,241 · 25.5%Low 1,210 · 24.9%Moderate 776 · 16%High 192 · 4%

Summary of findings table ‐ Ondansetron vs placebo

Risk for at least one adverse event per patient · patients with chronic kidney disease (CKD) pruritus

It is very uncertain whether summary of findings table ‐ Ondansetron changes risk for at least one adverse event per patient compared with placebo (very low certainty).

1 finding from 1 review

Antibiotics vs placebo or no intervention

All‐cause mortality · farmworkers, soldiers, and people in endemic areas

Summary of findings table ‐ Antibiotics showed no clear difference in all‐cause mortality compared with placebo or no intervention (low certainty).

1 finding from 1 review

Antibiotics vs other antibiotics

Clinical diagnosis of leptospirosis regardless of laboratory confirmation · farmworkers

It is very uncertain whether summary of findings table ‐ Antibiotics changes clinical diagnosis of leptospirosis regardless of laboratory… compared with other antibiotics (very low certainty).

1 finding from 1 review

Antibiotics vs other antibiotics

Laboratory‐confirmed leptospirosis · farmworkers

It is very uncertain whether summary of findings table ‐ Antibiotics changes clinical diagnosis of leptospirosis confirmed by laboratory diagnosis compared with other antibiotics (very low certainty).

2 findings from 1 review