Early childhood caries (ECC) - association with genetically predicted expression of TAS2R43 (chr12p13.2) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted expression of TAS2R43 was significantly associated with ECC in the TWAS (p = 8.78e-8); genetic association, ungraded.
1 finding from 1 review
Intervention not reported
Difference in summary sensitivity (NMA, Analysis 2)
1 finding from 1 review
Differential microbial abundance / taxa predictive of caries · Individuals providing oral (saliva/supragingival plaque) 16S rRNA microbiome samples; 2016 samples from 19 studies (mixed children and…
A group of genera/species (notably Selenomonas, Aggregatibacter, Actinomyces, Treponema) was predictive of caries, whereas Streptococcus was not (ungraded).
1 finding from 1 review
Meta-analysis of caries microbiome studies can improve upon disease prediction outcomes. 2022 All outcomesOral cavity microbiome (saliva and supragingival plaque samples); pooled across 19 international studies
Mean-decrease-accuracy discriminating taxa: Capnocytophaga HMT-338, Lactobacillus panis, Treponema HMT-230, Bifidobacterium longum, Delftia acidovorans, Staphylococcus schleiferi; higher log2FC in caries: Selenomonas HMT-146, Aggregatibacter actinomycetemcomitans, Actinomyces HMT-896, Treponema HMT-257; Streptococcus not predictive
19 studies · 2016 participants
GRADE not reported
Restoration failure · Children with carious primary teeth after vital or non-vital pulp therapy
In one RCT, composite resin had an annual failure rate of 0% after 2 years.
1 finding from 1 review
Weight gain · Healthy, term-born, normal-birth-weight infants aged 4-24 months (breastfed and/or formula-fed) in Western industrialized countries
Narratively, restrictive NRCF style tended to favor excess weight and coercive/pressuring style tended to favor lower weight (3 of 5 studies each; ungraded).
1 finding from 1 review
Intervention not reported
Difference in summary specificity (NMA, Analysis 2)
1 finding from 1 review
Correlation between daily urinary fluoride excretion (DUFE) and fluoride intake · Children and adults with 24-h urinary fluoride monitoring (9 studies reporting both intake and urine; Table 2)
Daily urinary fluoride excretion was not correlated with total daily fluoride intake or with fluoride intake from toothpaste (R2 < 0.07), based on nine studies (ungraded).
1 finding from 1 review
Dental caries prevalence · Children aged 12 years (plus or minus one year) in Africa
The pooled dental-caries prevalence was 0.3657 (95% CI 0.3065 to 0.4250); GRADE was not reported.
2 findings from 1 review
Prevalence 0.3657 [0.3065, 0.4250]
Studies not reported
GRADE not reported
Prevalence 0.356 [0.294, 0.417]
Studies not reported
GRADE not reported
Intervention not reported
Difference in summary sensitivity (NMA, Analysis 2)
1 finding from 1 review
Early childhood caries (ECC) - association with genetically predicted expression of SMIM10L1 (chr12p13.2) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted expression of SMIM10L1 was significantly associated with ECC in the TWAS (p = 1.70e-7); genetic association, ungraded.
1 finding from 1 review
Alpha diversity (Chao1, Observed, Shannon) · Adults providing oral (saliva/supragingival plaque) 16S rRNA microbiome samples
In adults, caries-vs-health alpha diversity differed for the Shannon index but not Chao1/Observed (ungraded).
1 finding from 1 review
Dental caries (association with no formal maternal education) · Children (deciduous and/or permanent dentition) in low- and middle-income countries
No formal maternal education showed a non-significant trend toward higher odds of dental caries (OR 1.34, 95% CI 0.76 to 2.36; 3 studies; not GRADE-rated).
1 finding from 1 review
Restoration failure · Children with carious primary teeth
No comparative effect estimate was reported; failure rates were 32% and 12%.
1 finding from 1 review
Treatment failure (annual failure rate) · Children with moderately deep dentine caries in primary molars, no pulp therapy
Etch-and-rinse adhesion failed more than self-etch (19.5% vs 7.0% annual failure) in one RCT; low quality of evidence (ungraded).
1 finding from 1 review
Enamel caries proportion · European adolescents aged 12 years
Pooled enamel caries proportion was 0.52 (I² = 100.0%).
1 finding from 1 review
Treatment failure (annual failure rate) · Children with previously unrestored, vital carious lesions in primary teeth (no pulp therapy); aged 1.5-11 years
Amalgam restorations in primary teeth showed a wide annual failure rate (1-28%) across 4 RCTs; the evidence is of low quality (high risk of bias; ungraded).
1 finding from 1 review
Treatment failure (annual failure rate) · Children with severely decayed maxillary primary incisors treated by pulpectomy (non-vital pulp therapy)
Composite strip crowns with composite posts had a low annual failure rate (2.3%) in maxillary primary incisors after pulpectomy (single high-risk-of-bias RCT; low quality of evidence; not GRADE-rated).
3 findings from 1 review
AFR 2.3
1 study · 54 participants
GRADE not reported
AFR 2.2
1 study · 54 participants
GRADE not reported
AFR 0
1 study · 54 participants
GRADE not reported
Dental development / dental age (mineralization chronology) · Children or adolescents
No significant overall difference in dental development between CLWH on ART and healthy controls (three studies, narrative synthesis).
1 finding from 1 review
Restoration failure · Children with carious primary teeth
No comparative effect estimate was reported; both arms had 16% failure.
1 finding from 1 review
Marginal adaptation (unacceptable marginal adaptation) · Patients with permanent dentition in need of restorations (all cavity types: Black's Class I, II, V, and non-carious cervical lesions)
Across follow-up periods, there was no statistically significant difference in unacceptable marginal adaptation between GIC and resin composite restorations.
6 findings from 1 review
Secondary caries and marginal adaptation of ion-releasing versus resin composite restorations: a systematic review and… 2022 All outcomes1 year, 18 months to 2 years, and 3 years · University, private practice, primary school, and multicenter settings · All types of cavities
RD 0.01 [-0.01, 0.03]
9 studies · 2725 participants
GRADE not reported
Secondary caries and marginal adaptation of ion-releasing versus resin composite restorations: a systematic review and… 2022 All outcomes3 years · Permanent dentition; university (majority), school, and private-practice settings across multiple countries (Turkey, Brazil, Sweden, India, Vietnam, Belgium, Germany, etc.)
RD 0.00 [-0.02, 0.02]
3 studies · 321 participants
Low
Secondary caries and marginal adaptation of ion-releasing versus resin composite restorations: a systematic review and… 2022 All outcomes3 years · University, private practice, primary school, and multicenter settings · All types of cavities
RD 0.00 [-0.02, 0.02]
3 studies · 321 participants
Low
Show 3 more findings
Secondary caries and marginal adaptation of ion-releasing versus resin composite restorations: a systematic review and… 2022 All outcomes1 year · University, private practice, primary school, and multicenter settings · All types of cavities
RD 0.01 [-0.02, 0.03]
9 studies · 1386 participants
Low
Secondary caries and marginal adaptation of ion-releasing versus resin composite restorations: a systematic review and… 2022 All outcomes18 months-2 years · Permanent dentition; university (majority), school, and private-practice settings across multiple countries (Turkey, Brazil, Sweden, India, Vietnam, Belgium, Germany, etc.)
RD 0.03 [-0.02, 0.08]
7 studies · 1018 participants
Low
Secondary caries and marginal adaptation of ion-releasing versus resin composite restorations: a systematic review and… 2022 All outcomes1 year · Permanent dentition; university (majority), school, and private-practice settings across multiple countries (Turkey, Brazil, Sweden, India, Vietnam, Belgium, Germany, etc.)
RD 0.01 [-0.02, 0.03]
9 studies · 1386 participants
Low