Findings

What do systematic reviews say?

4,736 questions · 15,265 findings · 1,163 reviews · Headline outcomes only

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No studies found 3,871 · 25.4%GRADE not reported 810 · 5.3%Very low 4,242 · 27.8%Low 3,879 · 25.4%Moderate 1,999 · 13.1%High 464 · 3%

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Omega‐3 (with risperidone and previous ASM) vs risperidone and previous ASM only

Seizure frequency · people with ADHD and epilepsy

1 finding from 1 review

Stimulant and non‐stimulant drug therapy for people with attention deficit hyperactivity disorder and epilepsy 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 56 participants
Low

Summary of findings table ‐ Systemic therapy vs control

Change in pain from baseline to end of intervention · women with early breast cancer

1 finding from 1 review

Systemic therapies for preventing or treating aromatase inhibitor‐induced musculoskeletal symptoms in early breast… 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 183 participants
Very low

Summary of findings table ‐ Systemic therapy vs control

Change in grip strength · women with early breast cancer

Summary of findings table ‐ Systemic therapy showed no clear difference in change in grip strength from baseline to end of intervention compared with control (low certainty).

1 finding from 1 review

Systemic therapies for preventing or treating aromatase inhibitor‐induced musculoskeletal symptoms in early breast… 2022 · Cochrane Headline outcomes only
RR 1.08 [0.37, 3.17]
1 study · 137 participants
Low

Summary of findings table ‐ Systemic therapy vs control

Change in pain from baseline to end of intervention · health problem or population

1 finding from 1 review

Systemic therapies for preventing or treating aromatase inhibitor‐induced musculoskeletal symptoms in early breast… 2022 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 1099 participants
Very low

Summary of findings table ‐ Systemic therapy vs control

Change in stiffness from baseline to end of intervention · health problem or population

1 finding from 1 review

Systemic therapies for preventing or treating aromatase inhibitor‐induced musculoskeletal symptoms in early breast… 2022 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 295 participants
Very low

Duct‐to‐mucosa pancreaticojejunostomy using the modified Blumgart technique vs duct‐to‐mucosa pancreaticojejunostomy using the traditional interrupted technique

Rate of surgical reintervention · adults undergoing open pancreaticoduodenectomy

It is very uncertain whether duct‐to‐mucosa pancreaticojejunostomy using the modified Blumgart… changes rate of surgical reintervention compared with duct‐to‐mucosa pancreaticojejunostomy using the traditional… (very low certainty).

1 finding from 1 review

Duct‐to‐mucosa versus other types of pancreaticojejunostomy for the prevention of postoperative pancreatic fistula… 2022 · Cochrane Headline outcomes only
RR 1.93 [0.18, 20.91]
1 study · 210 participants
Very low

Duct‐to‐mucosa vs invagination pancreaticojejunostomy

Rate of surgical reintervention · adults undergoing open pancreaticoduodenectomy

It is very uncertain whether duct‐to‐mucosa changes rate of surgical reintervention compared with invagination pancreaticojejunostomy (very low certainty).

1 finding from 1 review

Duct‐to‐mucosa versus other types of pancreaticojejunostomy for the prevention of postoperative pancreatic fistula… 2022 · Cochrane Headline outcomes only
RR 1.12 [0.65, 1.95]
10 studies · 1472 participants
Very low

Cuffed vs uncuffed endotracheal tubes

Surgical intervention (e.g. endoscopic balloon dilation, cricoid split, tracheostomy) for stridor or subglottic stenosis Time of measurement: during initial hospitalization · neonates

1 finding from 1 review

Cuffed versus uncuffed endotracheal tubes for neonates 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 69 participants
Very low

Prophylactic dopamine antagonist antiemetic medications vs placebo

Nausea severity · adults receiving intravenous opioids

1 finding from 1 review

Prophylactic antiemetics for adults receiving intravenous opioids in the acute care setting 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 191 participants
Low

Cervical pessary vs vaginal progesterone

Harm to offspring from the intervention · women with singleton pregnancies at risk of cervical insufficiency

1 finding from 1 review

Cervical pessary for preventing preterm birth in singleton pregnancies 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 11 participants
Low

Cervical pessary vs cervical cerclage

Harm to offspring from the intervention · women with singleton pregnancies at risk of cervical insufficiency

1 finding from 1 review

Cervical pessary for preventing preterm birth in singleton pregnancies 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 13 participants
Low

Cervical pessary vs no treatment

Harm to offspring from the intervention · women with singleton pregnancies at risk of cervical insufficiency

The review found no eligible studies for this question.

1 finding from 1 review

Cervical pessary for preventing preterm birth in singleton pregnancies 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Continuous vs intermittent bolus (nasogastric and orogastric tube) milk feeding ‐ all preterm infants less than 1500 grams

Rate of weight gain (g/kg/day) · preterm infants less than 1500 grams

1 finding from 1 review

Continuous nasogastric milk feeding versus intermittent bolus milk feeding for preterm infants less than 1500 grams 2021 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 433 participants
Very low

Continuous vs intermittent bolus (nasogastric and orogastric tube) milk feeding ‐ all preterm infants less than 1500 grams

End of intervention: rate of gain in length (cm/week) · preterm infants less than 1500 grams

1 finding from 1 review

Continuous nasogastric milk feeding versus intermittent bolus milk feeding for preterm infants less than 1500 grams 2021 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 433 participants
Low

Continuous vs intermittent bolus (nasogastric and orogastric tube) milk feeding ‐ all preterm infants less than 1500 grams

Growth: head circumference (cm/week) · preterm infants less than 1500 grams

1 finding from 1 review

Continuous nasogastric milk feeding versus intermittent bolus milk feeding for preterm infants less than 1500 grams 2021 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 433 participants
Low

Dipyridamole vs placebo

Number of related surgical or radiological interventions · people with ESRD receiving haemodialysis through an arteriovenous graft

The review found no eligible studies for this question.

1 finding from 1 review

Medical adjuvant treatment to increase patency of arteriovenous fistulae and grafts 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Dipyridamole plus aspirin vs placebo

Number of related surgical or radiological interventions · people with ESRD receiving haemodialysis through an arteriovenous graft

The review found no eligible studies for this question.

1 finding from 1 review

Medical adjuvant treatment to increase patency of arteriovenous fistulae and grafts 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Warfarin vs placebo

Number of related surgical or radiological interventions · people with ESRD receiving haemodialysis through an arteriovenous graft

The review found no eligible studies for this question.

1 finding from 1 review

Medical adjuvant treatment to increase patency of arteriovenous fistulae and grafts 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Fish oil vs placebo

Radiological or surgical intervention (up to 12 months) · people with ESRD receiving haemodialysis through an arteriovenous graft

Fish oil showed no clear difference in radiological or surgical intervention (up to 12 months) compared with placebo (moderate certainty).

1 finding from 1 review

Medical adjuvant treatment to increase patency of arteriovenous fistulae and grafts 2021 · Cochrane Headline outcomes only
OR 0.64 [0.36, 1.12]
1 study · 196 participants
Moderate

Clopidogrel vs placebo

Number of related surgical or radiological interventions · people with ESRD receiving haemodialysis through an arteriovenous fistula

Clopidogrel showed no clear difference in number of related surgical or radiological interventions (42 days) compared with placebo (moderate certainty).

1 finding from 1 review

Medical adjuvant treatment to increase patency of arteriovenous fistulae and grafts 2021 · Cochrane Headline outcomes only
OR 0.69 [0.26, 1.82]
1 study · 866 participants
Moderate