Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,532 questions · 2,642 findings · 483 reviews · Headline outcomes only

No studies found 534 · 20.2%GRADE not reported 82 · 3.1%Very low 641 · 24.3%Low 807 · 30.5%Moderate 472 · 17.9%High 106 · 4%

Intervention not reported

Orthostatic hypotension (adverse effect, post‐intervention) · people with Parkinson's disease

The intervention showed no clear difference in orthostatic hypotension (adverse effect, post‐intervention) (moderate certainty).

1 finding from 1 review

Intervention not reported

Hypertension (adverse effect, post‐intervention) · people with Parkinson's disease

The intervention showed no clear difference in hypertension (adverse effect, post‐intervention) (moderate certainty).

1 finding from 1 review

Intervention not reported

Hypertension (adverse effect, post‐intervention) · people with Parkinson's disease

The intervention showed no clear difference in hypertension (adverse effect, post‐intervention) (moderate certainty).

1 finding from 1 review

Intervention not reported

Hypertension (adverse effect, post‐intervention) · people with Parkinson's disease

The intervention showed no clear difference in hypertension (adverse effect, post‐intervention) (moderate certainty).

1 finding from 1 review

Intervention not reported

Orthostatic hypotension (adverse effect, post‐intervention) · people with Parkinson's disease

It is very uncertain whether the intervention changes orthostatic hypotension (adverse effect, post‐intervention) (very low certainty).

1 finding from 1 review

Intervention not reported

Hypertension (adverse effect, post‐intervention) · people with Parkinson's disease

The intervention showed no clear difference in hypertension (adverse effect, post‐intervention) (moderate certainty).

1 finding from 1 review

Treatment route: intravenous corticosteroid vs oral corticosteroid

Treatment failure Need for additional treatment · exacerbations of COPD

Treatment route: intravenous corticosteroid showed no clear difference in treatment failure Need to intensify therapy compared with oral corticosteroid (moderate certainty).

1 finding from 1 review

Behavioural intervention vs control

Smoking cessation at time of surgery ‐ Intensive behavioural intervention (multiple contacts, initiated at least 4 weeks before surgery) · People awaiting surgery

Behavioural intervention probably leads to higher smoking cessation at time of surgery ‐ Intensive behavioural… compared with control (moderate certainty).

1 finding from 1 review

Behavioural intervention vs control

Postoperative morbidity: Any complication ‐ Intensive intervention · People awaiting surgery

Behavioural intervention probably leads to lower postoperative morbidity: Any complication ‐ Intensive intervention compared with control (moderate certainty).

1 finding from 1 review

CERA vs other ESA

Adverse events: hypertension · patients with the anaemia of end‐stage kidney disease undergoing dialysis

CERA showed no clear difference in numbers of adverse events due to hypertension: CERA every 2 weeks… compared with other ESA (high certainty).

1 finding from 1 review

Intervention not reported

Presence of PHN 6 months after the onset of the acute herpetic rash2 Clinical diagnostic criteria for PHN in any intensity · people with acute herpes zoster1
1 finding from 1 review

Intervention not reported

Presence of PHN 4 months after the onset of the acute herpetic rash Clinical diagnostic criteria for PHN in any intensity · people with acute herpes zoster1

The intervention showed no clear difference in presence of PHN 4 months after the onset of the acute herpetic rash… (high certainty).

1 finding from 1 review

Antibiotics vs placebo

Mortality and morbidity prior to discharge (Neonatal intensive care admissions) · Women with meconium‐stained amniotic fluid in labour, gestational age more than 24 weeks

Antibiotic showed no clear difference in mortality and morbidity prior to discharge (Neonatal intensive care… compared with placebo (low certainty).

1 finding from 1 review