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Evidence found and GRADE certainty

2,297 questions · 3,638 findings · 215 reviews · Oral Health

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No studies found 98 · 2.7%GRADE not reported 2,946 · 81%Very low 263 · 7.2%Low 158 · 4.3%Moderate 137 · 3.8%High 36 · 1%

Food and nonalcoholic beverage marketing (exposure) vs No, less, or less powerful food marketing

Food intake · Children and adolescents (general population, aged under 20 years)

Food marketing was associated with a significant increase in children's food intake (pooled SMD, 0.25; combined RCT and nonrandomized evidence).

3 findings from 1 review

Resin-based fissure sealant vs Fluoride varnish

DMFS (decayed, missing, filled surfaces) increment, occlusal surfaces · Schoolchildren aged 6-12 years with sound occlusal surfaces of the first permanent molars

Pit and fissure sealant and fluoride varnish showed no statistically significant difference in DMFS increment at 24 months (SMD -0.13, 95% CI -0.67 to 0.40; I2=92%; not GRADE-rated).

1 finding from 1 review

Responsive complementary feeding (RCF) vs Other models of complementary feeding (traditional/non-responsive CF)

Overweight/obesity risk · Healthy, term-born, normal-birth-weight infants aged 4-24 months (breastfed and/or formula-fed) in Western industrialized countries

Responsive complementary feeding probably reduces the risk of overweight/obesity versus other feeding models (RR 0.41, 95% CI 0.24 to 0.71; moderate certainty).

1 finding from 1 review

Dental caries assessment (WHO/clinical diagnostic criteria; caries = DMFT>0) vs None (descriptive prevalence review; subgroup analyses by urban/rural status, country and year)

Dental caries prevalence · 12-year-old children (permanent dentition) in Africa

Pooled caries prevalence in Uganda was 0.27 (95% CI 0.126 to 0.418; 3 article(s); not GRADE-rated).

23 findings from 1 review
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Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy

Dental caries prevalence and severity · Children and adolescents (<18 years) living with HIV (CLWH)

No significant difference in dental caries/severity between ART regimens (very low certainty).

1 finding from 1 review

Living with HIV and undergoing antiretroviral therapy (ART/HAART) vs Healthy HIV-negative controls

Kaposi's sarcoma (WHO clinical stage 4) · Children or adolescents

No eligible studies reported Kaposi's sarcoma.

1 finding from 1 review

Pulpotomy (full or partial) vs None (single-arm pooled success proportion)

Overall success (composite of clinical and radiographic success) · Human permanent teeth with irreversible pulpitis due to carious pulp exposure

Among 6 observational studies, pooled pulpotomy success was 92.6 per 100 (95% CI 0.86-0.96), very low certainty.

4 findings from 1 review
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Responsive complementary feeding (RCF) vs usual care

Z score BMI · Healthy, term-born, normal-birth-weight infants aged 4-24 months (breastfed and/or formula-fed) in Western industrialized countries

In one RCT, responsive complementary feeding lowered BMIz at 13 months versus control (0.23 vs 0.42, p=0.01; low certainty).

1 finding from 1 review

Pulpotomy with Calcium Enriched Mixture (CEM) vs Pulpotomy with calcium hydroxide (Ca(OH)2)

Overall success (composite of clinical and radiographic success) · Human permanent teeth with irreversible pulpitis due to carious pulp exposure

CEM and calcium hydroxide did not differ significantly in pulpotomy success (indirect comparison); ungraded.

1 finding from 1 review

Living with HIV and undergoing antiretroviral therapy (ART/HAART) vs Healthy HIV-negative controls

Salivary immunoglobulin A (SIgA) concentration · Children or adolescents

No significant difference in total salivary IgA between CLWH and healthy controls, though anti-Candida SIgA was higher in HIV groups; narrative only.

1 finding from 1 review

Food marketing exposure or greater marketing power vs No, less, or less powerful food marketing

Food choice · Children and adolescents (general population, aged under 20 years)

In crossover studies with binary outcomes, food marketing had no clear association with food choice (OR 3.45, 95% CI 0.97 to 12.43; ungraded).

1 finding from 1 review

Caries severity measurement (mean number of decayed, missing and filled permanent teeth, DMFT; WHO criteria) vs None (descriptive prevalence review; subgroup analyses by urban/rural status, country and year)

Dental caries · 12-year-old children (permanent dentition) in Africa

Pooled mean DMFT in Sudan was 0.49 (95% CI 0.461 to 0.519; 1 article(s); not GRADE-rated).

22 findings from 1 review
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Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive)

Linear gingival erythema prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

No significant difference in linear gingival erythema between CLWH with and without ART (very low certainty).

1 finding from 1 review

Food and nonalcoholic beverage marketing (exposure) vs No, less, or less powerful food marketing

Food preference · Children and adolescents (general population, aged under 20 years)

Food marketing was associated with increased food preference (pooled SMD, 0.30; combined evidence).

3 findings from 1 review

Caries experience measurement (mean D(M)FS, enamel lesions included) vs None (descriptive prevalence review; subgroup analyses by urban/rural status, country and year)

Dental caries · European adolescents aged 12–19 years

Mean caries experience (DMFS) in subgroup 'Examination type: full-mouth' was 6.56 (95% CI 4.55 to 9.47; 12 studies).

11 findings from 1 review
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