Findings

What do systematic reviews say?

2,532 questions · 2,642 findings · 483 reviews · Headline outcomes only

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No studies found 534 · 20.2%GRADE not reported 82 · 3.1%Very low 641 · 24.3%Low 807 · 30.5%Moderate 472 · 17.9%High 106 · 4%

Routine fetal movement counting vs mixed or undefined fetal movement counting

Perinatal death or severe morbidity · Pregnant women who had reached the gestational age of fetal viability

The review found no eligible studies for this question.

1 finding from 1 review

Fetal movement counting for assessment of fetal wellbeing 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Quinine vs a quinine‐vitamin E combination (Q‐Vel)

Cramp intensity (on 3‐point scale; 1 = mild; 2 = moderate; 3 = severe) · patients with muscle cramps

1 finding from 1 review

Quinine for muscle cramps 2015 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 510 participants
Low

Quinine vs placebo

Cramp intensity (on 3‐point scale; 1 = mild; 2 = moderate; 3 = severe) · patients with muscle cramps

1 finding from 1 review

Quinine for muscle cramps 2015 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 666 participants
Moderate

Quinine vs vitamin E

Cramp intensity (on 3‐point scale; 1 = mild; 2 = moderate; 3 = severe) · patients with muscle cramps

1 finding from 1 review

Quinine for muscle cramps 2015 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 513 participants
Moderate

Intervention not reported

Pain intensity Various pain scales. (median · participants with osteoarthritis of the knee

The intervention showed no clear difference in pain intensity Various pain scales. (median (low certainty).

1 finding from 1 review

Intra‐articular corticosteroid for knee osteoarthritis 2015 · Cochrane Headline outcomes only
no estimate extracted
26 studies · 1749 participants
Low

Intervention not reported

Hypotensive events · patients with acute kidney injury

The intervention probably leads to lower hypotensive events (moderate certainty).

1 finding from 1 review

Bicarbonate‐ versus lactate‐buffered solutions for acute continuous haemodiafiltration or haemofiltration 2015 · Cochrane Headline outcomes only
RR 0.44 [0.26, 0.75]
1 study · 20 participants
Moderate

Group antenatal care vs individual antenatal care (adjusted data)

Neonatal admission to NICU · pregnant women accessing prenatal care

Group antenatal care showed no clear difference in neonatal intensive care unit (NICU) admission (admission of baby to… compared with individual antenatal care (adjusted data) (moderate certainty).

1 finding from 1 review

Group versus conventional antenatal care for women 2015 · Cochrane Headline outcomes only
RR 1.48 [0.63, 3.45]
2 studies · 1315 participants
Moderate

Computerised antenatal CTG vs traditional antenatal CTG (women at increased risk of complications)

Admission to neonatal special care unit or intensive care unit · Pregnant women with/without complications

The review found no eligible studies for this question.

1 finding from 1 review

Antenatal cardiotocography for fetal assessment 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Traditional antenatal CTG vs no antenatal CTG (women at increased risk of complication)

Admission to neonatal special care unit or intensive care unit · Pregnant women with/without complications

Traditional antenatal CTG showed no clear difference in admission to neonatal special care unit or intensive care unit compared with no antenatal CTG (women at increased risk of complication) (low certainty).

1 finding from 1 review

Antenatal cardiotocography for fetal assessment 2015 · Cochrane Headline outcomes only
RR 1.08 [0.84, 1.39]
2 studies · 883 participants
Low

Tranexamic acid vs placebo/no treatment

Serious maternal morbidity or death · pregnant women undergoing vaginal or caesarean birth who received TA for the prevention of postpartum haemorrhage

1 finding from 1 review

Tranexamic acid for preventing postpartum haemorrhage 2015 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 1511 participants
Low

Lidocaine vs amiodarone

Hypotension · patients with myocardial infarction

It is very uncertain whether lidocaine changes hypotension compared with amiodarone (very low certainty).

1 finding from 1 review

Prophylactic lidocaine for myocardial infarction 2015 · Cochrane Headline outcomes only
RR 0.14 [0.01, 2.6]
1 study · 25 participants
Very low

Lidocaine vs dimethylammonium

Hypotension · patients with myocardial infarction

It is very uncertain whether lidocaine changes hypotension compared with dimethylammonium (very low certainty).

1 finding from 1 review

Prophylactic lidocaine for myocardial infarction 2015 · Cochrane Headline outcomes only
RR 0.85 [0.28, 2.59]
1 study · 31 participants
Very low

Planned early birth vs expectant management

Significant maternal morbidity one or more of the following: significant postpartum haemorrhage requiring blood transfusion; maternal admission to intensive care unit; uterine rupture; hysterectomy · pregnant women with a term suspected compromised baby

Planned early delivery showed no clear difference in significant maternal morbidity one or more of the following:… compared with expectant management (low certainty).

1 finding from 1 review

Planned early delivery versus expectant management of the term suspected compromised baby for improving outcomes 2015 · Cochrane Headline outcomes only
RR 0.92 [0.38, 2.22]
1 study · 459 participants
Low

Hypnotherapy vs control

Severity of attack of recurrent herpes labialis during use of the preventative intervention (change in intensity) · participants with recurrent herpes labialis

1 finding from 1 review

Interventions for prevention of herpes simplex labialis (cold sores on the lips) 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 21 participants
Very low

Summary of findings table 4: refining rehabilitation: three months of postoperative night splinting with hand therapy vs hand therapy alone

Total active extension at 3 months Major outcome group 3 (early objective measurement) Total active extension (TAE) of MCPJ, PIPJ and DIPJ; higher value indicates loss of extension and a worse outcome · 210 participants with Dupuytren's disease of the fingers in 2 studies (225 digits reported across all studies) (Collis 2013;…

1 finding from 1 review

Surgery for Dupuytren's contracture of the fingers 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 225 participants
Low

Summary of findings table 1: comparison of operation types: early results of needle fasciotomy vs limited fasciectomy

Early angular outcome at 6 weeks for Tubiana grade I disease (total passive extension deficit (TPED) of the MCPJ, PIPJ and DIPJ for preoperative contractures with a TPED of 0 to 45 degrees) Early angular outcome at 6 weeks for Tubiana grade II dis... · 125 hands in 121 participants with Dupuytren's disease of the fingers for early outcomes (van Rijssen 2006)

1 finding from 1 review

Surgery for Dupuytren's contracture of the fingers 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 57 participants
Low

Tinzaparin vs placebo

Pain intensityNumeric pain scale · people with sickle cell disease

1 finding from 1 review

Low‐molecular‐weight heparins for managing vaso‐occlusive crises in people with sickle cell disease 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 253 participants
Very low

Dalteparin vs placebo

Pain intensityVAS 0‐10. Scale from: 0 to 10. · sickle cell disease

1 finding from 1 review

Low‐molecular‐weight heparins for managing vaso‐occlusive crises in people with sickle cell disease 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 35 participants
Very low

Intervention not reported

ICU ‐ intensive care unit · adults undergoing surgery requiring cardiac bypass

The review found no eligible studies for this question.

1 finding from 1 review

HMG CoA reductase inhibitors (statins) for preventing acute kidney injury after surgical procedures requiring cardiac… 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Hypertension (adverse effect, post‐intervention) · people with Parkinson's disease

The intervention showed no clear difference in hypertension (adverse effect, post‐intervention) (moderate certainty).

1 finding from 1 review

Interventions for fatigue in Parkinson's disease 2015 · Cochrane Headline outcomes only
RR 0.53 [0.27, 1.06]
1 study · 1176 participants
Moderate