Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,747 questions · 3,943 findings · 594 reviews

No studies found 784 · 19.9%GRADE not reported 530 · 13.4%Very low 1,040 · 26.4%Low 981 · 24.9%Moderate 444 · 11.3%High 164 · 4.2%

Cervical cerclage in combination with antibiotics and tocolytics vs cervical cerclage

Serious neonatal morbidity

It is very uncertain whether cervical cerclage in combination with antibiotics and tocolytics changes serious neonatal morbidity (Reported in Miller 2014 as 'composite… compared with cervical cerclage alone (very low certainty).

1 finding from 1 review

Laser‐assisted in‐situ keratomileusis (LASIK) with a mechanical microkeratome vs LASIK with a femtosecond laser

Mean refractive error expressed as mean spherical equivalent post‐treatment. ‐ 12 months · adults (18 years) with more than 0.5 diopters of myopia or myopic astigmatism
1 finding from 1 review

Vitamin D given to lactating mothers vs placebo or no treatment

Nutritional rickets ‐ radiological · term breastfed infants to prevent vitamin D deficiency and improve bone health

It is very uncertain whether vitamin D given to lactating mothers changes nutritional rickets ‐ radiological compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Vitamin D given to lactating mothers vs placebo or no treatment

Nutritional rickets ‐ biochemical Alkaline phosphatase, calcium and phosphate levels. · term breastfed infants to prevent vitamin D deficiency and improve bone health

Vitamin D given to lactating mothers may leads to lower nutritional rickets ‐ biochemical Alkaline phosphatase, calcium and… compared with placebo or no treatment (low certainty).

1 finding from 1 review

Intervention not reported

Aldosterone antagonists plus loop diuretics plus systemic vasoconstrictors (No direct RCT) · people with liver cirrhosis and ascites

It is very uncertain whether the intervention changes aldosterone antagonists plus loop diuretics plus systemic… (very low certainty).

1 finding from 1 review

Intervention not reported

Aldosterone antagonists plus loop diuretics plus systemic vasoconstrictors plus paracentesis plus fluid replacement (No direct RCT) · people with liver cirrhosis and ascites

It is very uncertain whether the intervention changes aldosterone antagonists plus loop diuretics plus systemic… (very low certainty).

1 finding from 1 review

Intervention not reported

Aldosterone antagonists plus loop diuretics plus systemic vasoconstrictors plus systemic vasodilator (No direct RCT) · people with liver cirrhosis and ascites

It is very uncertain whether the intervention changes aldosterone antagonists plus loop diuretics plus systemic… (very low certainty).

1 finding from 1 review

Intervention not reported

Paracentesis plus systemic vasoconstrictors (4 RCTs; 145 participants) · people with liver cirrhosis and ascites

It is very uncertain whether the intervention changes paracentesis plus systemic vasoconstrictors (4 RCTs; 145 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Paracentesis plus systemic vasoconstrictors (1 RCT; 25 participants) · people with liver cirrhosis and ascites

It is very uncertain whether the intervention changes paracentesis plus systemic vasoconstrictors (1 RCT; 25 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Paracentesis plus systemic vasoconstrictors (3 RCTs; 114 participants) · people with liver cirrhosis and ascites

It is very uncertain whether the intervention changes paracentesis plus systemic vasoconstrictors (3 RCTs; 114 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Paracentesis plus systemic vasoconstrictors (5 RCTs; 165 participants) · people with liver cirrhosis and ascites

It is very uncertain whether the intervention changes paracentesis plus systemic vasoconstrictors (5 RCTs; 165 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Baricitinib (1 RCT; 75 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes baricitinib (1 RCT; 75 participants) (very low certainty).

1 finding from 1 review

Very early treatment vs expectant management

Severe intraventricular hemorrhage in infants who received neuroimaging · preterm infants

Very early treatment showed no clear difference in severe Intraventricular hemorrhage (grades III and IV) compared with expectant management (moderate certainty).

1 finding from 1 review

Early treatment vs expectant management

Severe intraventricular hemorrhage in infants who received neuroimaging · preterm infants

Early treatment showed no clear difference in severe Intraventricular hemorrhage (grades III and IV) compared with expectant management (low certainty).

1 finding from 1 review

Extended specialised early intervention (SEI) teams vs standard SEI teams plus treatment

Service use: admission to psychiatric hospital (assessed by proportion admitted at end of treatment) · recent‐onset psychosis

Extended specialised early intervention (SEI) teams showed no clear difference in service use: admission to psychiatric hospital at end of treatment… compared with standard SEI teams plus treatment (low certainty).

1 finding from 1 review

Specialised early intervention (SEI) vs treatment

Service use: admission to psychiatric hospital (assessed by proportion admitted at end of treatment) · recent‐onset psychosis (less than three years since the start of psychotic symptoms and either first or second psychotic episode)

Specialised early intervention (SEI) showed no clear difference in service use: admission to psychiatric hospital (assessed by… compared with treatment (low certainty).

1 finding from 1 review