What do systematic reviews say?

Paracetamol plus ibuprofen (oral or IV) vs ibuprofen plus placebo (oral or IV) or no intervention

Paracetamol plus ibuprofen (oral or IV) showed no clear difference in failure of PDA closure after first course of treatment (assessed by… compared with ibuprofen plus placebo (oral or IV) or no intervention (low certainty).

• Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants 2022 · Cochrane Headline outcomes only
  RR 0.77 [0.43, 1.36]
  2 studies · 111 participants
  Low

Paracetamol plus ibuprofen (oral or IV) vs ibuprofen plus placebo (oral or IV) or no intervention

The review found no eligible studies for this question.

• Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Paracetamol plus ibuprofen (oral or IV) vs ibuprofen plus placebo (oral or IV) or no intervention

Paracetamol plus ibuprofen (oral or IV) showed no clear difference in necrotizing enterocolitis during initial hospital stay (radiological… compared with ibuprofen plus placebo (oral or IV) or no intervention (low certainty).

• Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants 2022 · Cochrane Headline outcomes only
  RR 0.33 [0.01, 7.45]
  1 study · 24 participants
  Low

Paracetamol vs ibuprofen

Paracetamol showed no clear difference in all‐cause mortality during initial hospital stay(by clinical… compared with ibuprofen (moderate certainty).

• Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants 2022 · Cochrane Headline outcomes only
  RR 1.09 [0.8, 1.48]
  8 studies · 734 participants
  Moderate

Paracetamol vs ibuprofen

Paracetamol showed no clear difference in necrotizing enterocolitisduring initial hospital stay (by… compared with ibuprofen (moderate certainty).

• Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants 2022 · Cochrane Headline outcomes only
  RR 1.3 [0.87, 1.94]
  10 studies · 1015 participants
  Moderate

Synbiotic vs control

• Synbiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants 2022 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 907 participants
  Low

Synbiotic vs control

• Synbiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants 2022 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 925 participants
  Low

Synbiotic vs control

• Synbiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants 2022 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 707 participants
  Very low

Synbiotic vs control

The review found no eligible studies for this question.

• Synbiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

• Push versus gravity for intermittent bolus gavage tube feeding of preterm and low birth weight infants 2021 · Cochrane Headline outcomes only
  no estimate extracted
  0 participants
  GRADE not reported

Intervention not reported

• Push versus gravity for intermittent bolus gavage tube feeding of preterm and low birth weight infants 2021 · Cochrane Headline outcomes only
  no estimate extracted
  0 participants
  GRADE not reported

Intervention not reported

• Push versus gravity for intermittent bolus gavage tube feeding of preterm and low birth weight infants 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 31 participants
  Very low

Intervention not reported

• Push versus gravity for intermittent bolus gavage tube feeding of preterm and low birth weight infants 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 31 participants
  Very low

Intervention not reported

• Push versus gravity for intermittent bolus gavage tube feeding of preterm and low birth weight infants 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 31 participants
  Very low

Intervention not reported

• Push versus gravity for intermittent bolus gavage tube feeding of preterm and low birth weight infants 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 31 participants
  Very low

High vs standard volume of unfortified human milk or term formula

It is very uncertain whether high changes necrotising enterocolitis compared with standard volume of unfortified human milk or term formula (very low certainty).

• High versus standard volume enteral feeds to promote growth in preterm or low birth weight infants 2021 · Cochrane Headline outcomes only
  RR 1.03 [0.07, 15.78]
  1 study · 61 participants
  Very low

High vs standard volume of unfortified human milk or term formula

• High versus standard volume enteral feeds to promote growth in preterm or low birth weight infants 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 61 participants
  Moderate

High vs standard volume of unfortified human milk or term formula

• High versus standard volume enteral feeds to promote growth in preterm or low birth weight infants 2021 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

High vs standard volume of unfortified human milk or term formula

• High versus standard volume enteral feeds to promote growth in preterm or low birth weight infants 2021 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

High vs standard volume of unfortified human milk or term formula

• High versus standard volume enteral feeds to promote growth in preterm or low birth weight infants 2021 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported