Cochrane · systematic review · CD014067
Synbiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants
Sharif, S, Heath, PT, Oddie, SJ, et al. · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
4
current version
GRADE rated
3
No studies
1
Included studies
NR
No studies 1 · 25%Ungraded 0 · 0%Very low 1 · 25%Low 2 · 50%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Synbiotics compared to control in very preterm or very low birth weight infants
Population: very preterm or very low birth weight infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Necrotising enterocolitis (before hospital discharge) Synbiotics vs control | no estimate extracted | 6 studies · 907 participants | Low Downgraded: risk of bias |
Mortality (all‐cause before hospital discharge) Synbiotics vs control | no estimate extracted | 6 studies · 925 participants | Low Downgraded: risk of bias, imprecision |
Late‐onset Invasive infection (before hospital discharge) Synbiotics vs control | no estimate extracted | 5 studies · 707 participants | Very low Downgraded: risk of bias, imprecision |
Neurodevelopmental impairment (assessed beyond infancy) Synbiotics vs control | no estimate extracted | NR | No studies |