Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

127 questions · 132 findings · 13 reviews

No studies found 13 · 9.8%GRADE not reported 4 · 3%Very low 31 · 23.5%Low 33 · 25%Moderate 27 · 20.5%High 24 · 18.2%

Pregabalin or Gabapentin vs control or placebo medications

Adverse event nausea and vomiting (0 to 24 hours) · adults undergoing brain surgery

Pregabalin or Gabapentin may leads to lower adverse event nausea and vomiting (0 to 24 hours) compared with control or placebo medications (low certainty).

1 finding from 1 review

Pregabalin 300 mg vs placebo

Patient satisfaction with analgesia ‐ not reported · women having medical abortion before 14 weeks' gestation

Summary of findings table ‐ Pregabalin 300 mg showed no clear difference in patient satisfaction with analgesia compared with placebo (low certainty).

1 finding from 1 review

Pregabalin 300 mg vs placebo

Patient satisfaction with abortion care overall ‐ not reported · women having medical abortion before 14 weeks' gestation

Summary of findings table ‐ Pregabalin 300 mg showed no clear difference in patient satisfaction with abortion care overall compared with placebo (low certainty).

1 finding from 1 review

Pregabalin vs placebo

Treatment‐related adverse effects · adults and children with sickle cell disease experiencing neuropathic pain

It is very uncertain whether summary of findings ‐ Pharmacological intervention (pregabalin) changes treatment‐related adverse effects compared with placebo (very low certainty).

1 finding from 1 review