Cochrane · systematic review · CD013525
Pain management for medical abortion before 14 weeks’ gestation
Reynolds-Wright, JJ, Woldetsadik, MA, Morroni, C, et al. · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
Fertility RegulationAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
44
current version
GRADE rated
20
No studies
24
Included studies
NR
No studies 24 · 54.5%Ungraded 0 · 0%Very low 3 · 6.8%Low 16 · 36.4%Moderate 1 · 2.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings table ‐ Ibuprofen 1600 mg compared to paracetamol 2000 mg for women having medical abortion before 14 weeks? gestation
Population: women having medical abortion before 14 weeks' gestation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain score Summary of findings table ‐ Ibuprofen 1600 mg vs paracetamol 2000 mg | no estimate extracted | 1 study · 108 participants | Moderate Downgraded: imprecision |
Gastrointestinal side effects (nausea) ‐ not reported Summary of findings table ‐ Ibuprofen 1600 mg vs paracetamol 2000 mg | no estimate extracted | NR | No studies |
Gastroinestinal side effects (vomiting) ‐ not reported Summary of findings table ‐ Ibuprofen 1600 mg vs paracetamol 2000 mg | no estimate extracted | NR | No studies |
Gastrointestinal side effects (diarrhoea) ‐ not reported Summary of findings table ‐ Ibuprofen 1600 mg vs paracetamol 2000 mg | no estimate extracted | NR | No studies |
Complete abortion rate Summary of findings table ‐ Ibuprofen 1600 mg vs paracetamol 2000 mg | OR 2.11 [0.64, 6.92] | 1 study · 108 participants | Low Downgraded: imprecision |
Induction to expulsion interval ‐ not reported Summary of findings table ‐ Ibuprofen 1600 mg vs paracetamol 2000 mg | no estimate extracted | NR | No studies |
Unscheduled contact with care ‐ not reported Summary of findings table ‐ Ibuprofen 1600 mg vs paracetamol 2000 mg | no estimate extracted | NR | No studies |
Patient satisfaction with analgesia ‐ not reported Summary of findings table ‐ Ibuprofen 1600 mg vs paracetamol 2000 mg | no estimate extracted | NR | No studies |
Patient satisfaction with abortion care overall ‐ not reported Summary of findings table ‐ Ibuprofen 1600 mg vs paracetamol 2000 mg | no estimate extracted | NR | No studies |
Summary of findings table ‐ Pregabalin 300 mg compared to placebo for women having medical abortion before 14 weeks? gestation
Population: women having medical abortion before 14 weeks' gestation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain score Summary of findings table ‐ Pregabalin 300 mg vs placebo | no estimate extracted | 1 study · 107 participants | Low Downgraded: imprecision |
Gastrointestinal side effects (nausea) Summary of findings table ‐ Pregabalin 300 mg vs placebo | OR 0.85 [0.33, 2.19] | 1 study · 107 participants | Low Downgraded: imprecision |
Gastrointestinal side effects (vomiting) Summary of findings table ‐ Pregabalin 300 mg vs placebo | OR 0.76 [0.35, 1.63] | 1 study · 107 participants | Low Downgraded: imprecision |
Gastrointestinal side effects (diarrhoea) Summary of findings table ‐ Pregabalin 300 mg vs placebo | OR 0.82 [0.38, 1.76] | 1 study · 107 participants | Low Downgraded: imprecision |
Complete abortion rate ‐ not reported Summary of findings table ‐ Pregabalin 300 mg vs placebo | no estimate extracted | NR | No studies |
Induction to expulsion interval ‐ not reported Summary of findings table ‐ Pregabalin 300 mg vs placebo | no estimate extracted | NR | No studies |
Unscheduled contact with care ‐ not reported Summary of findings table ‐ Pregabalin 300 mg vs placebo | no estimate extracted | NR | No studies |
Patient satisfaction with analgesia Summary of findings table ‐ Pregabalin 300 mg vs placebo | OR 0.97 [0.42, 2.21] | 1 study · 104 participants | Low Downgraded: imprecision |
Patient satisfaction with abortion care overall Summary of findings table ‐ Pregabalin 300 mg vs placebo | OR 1.84 [0.8, 4.22] | 1 study · 105 participants | Low Downgraded: imprecision |
Summary of findings table ‐ Ibuprofen 800 mg compared to placebo for women having medical abortion before 14 weeks? gestation
Population: women having medical abortion before 14 weeks' gestation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain score Summary of findings table ‐ Ibuprofen 800 mg vs placebo | no estimate extracted | 1 study · 61 participants | Low Downgraded: imprecision |
Gastrointestinal side effects (nausea) Summary of findings table ‐ Ibuprofen 800 mg vs placebo | OR 1.52 [0.53, 4.37] | 1 study · 61 participants | Low Downgraded: imprecision |
Gastrointestinal side effects (vomiting) Summary of findings table ‐ Ibuprofen 800 mg vs placebo | OR 0.19 [0.04, 0.97] | 1 study · 61 participants | Low Downgraded: imprecision |
Gastrointestinal side effects (diarrhoea) ‐ not reported Summary of findings table ‐ Ibuprofen 800 mg vs placebo | no estimate extracted | NR | No studies |
Complete abortion rate Summary of findings table ‐ Ibuprofen 800 mg vs placebo | OR 0.69 [0.17, 2.85] | 1 study · 61 participants | Low Downgraded: imprecision |
Induction to expulsion interval ‐ not reported Summary of findings table ‐ Ibuprofen 800 mg vs placebo | no estimate extracted | NR | No studies |
Unscheduled contact with care ‐ not reported Summary of findings table ‐ Ibuprofen 800 mg vs placebo | no estimate extracted | NR | No studies |
Patient satisfaction with analgesia ‐ not reported Summary of findings table ‐ Ibuprofen 800 mg vs placebo | no estimate extracted | NR | No studies |
Patient satisfaction with abortion care overall ‐ not reported Summary of findings table ‐ Ibuprofen 800 mg vs placebo | no estimate extracted | NR | No studies |
Summary of findings table ‐ Ambulation compared to non‐ambulation for women having medical abortion before 14 weeks? gestation
Population: women having medical abortion before 14 weeks' gestation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain score Summary of findings table ‐ Ambulation vs non‐ambulation | no estimate extracted | 1 study · 130 participants | Very low Downgraded: risk of bias, imprecision |
Gastrointestinal side effects (nausea) ‐ not reported Summary of findings table ‐ Ambulation vs non‐ambulation | no estimate extracted | NR | No studies |
Gastrointestinal side effects (vomiting) ‐ not reported Summary of findings table ‐ Ambulation vs non‐ambulation | no estimate extracted | NR | No studies |
Gastrointestinal side effects (diarrhoea) ‐ not reported Summary of findings table ‐ Ambulation vs non‐ambulation | no estimate extracted | NR | No studies |
Complete abortion rate Summary of findings table ‐ Ambulation vs non‐ambulation | no estimate extracted | 1 study · 1 participants | Very low Downgraded: risk of bias, imprecision |
Induction to expulsion interval Summary of findings table ‐ Ambulation vs non‐ambulation | no estimate extracted | 1 study · 130 participants | Very low Downgraded: risk of bias, imprecision |
Unscheduled contact with care ‐ not reported Summary of findings table ‐ Ambulation vs non‐ambulation | no estimate extracted | NR | No studies |
Patient satisfaction with analgesia ‐ not reported Summary of findings table ‐ Ambulation vs non‐ambulation | no estimate extracted | NR | No studies |
Patient satisfaction with abortion care overall ‐ not reported Summary of findings table ‐ Ambulation vs non‐ambulation | no estimate extracted | NR | No studies |
Summary of findings table ‐ Therapeutic ibuprofen 800 mg compared to prophylactic ibuprofen 800 mg women having medical abortion before 14 weeks? gestation
Population: women having medical abortion before 14 weeks' gestation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain score Summary of findings table ‐ Therapeutic ibuprofen 800 mg vs prophylactic ibuprofen 800 mg women having medical abortion before 14 weeks? gestation | no estimate extracted | 1 study · 228 participants | Low Downgraded: risk of bias, imprecision |
Gastrointestinal side effects (nausea and/or vomiting) Summary of findings table ‐ Therapeutic ibuprofen 800 mg vs prophylactic ibuprofen 800 mg women having medical abortion before 14 weeks? gestation | OR 1.67 [0.99, 2.83] | 1 study · 228 participants | Low Downgraded: risk of bias, imprecision |
Gastrointestinal side effects (diarrhoea) ‐ not reported Summary of findings table ‐ Therapeutic ibuprofen 800 mg vs prophylactic ibuprofen 800 mg women having medical abortion before 14 weeks? gestation | no estimate extracted | NR | No studies |
Complete abortion rate Summary of findings table ‐ Therapeutic ibuprofen 800 mg vs prophylactic ibuprofen 800 mg women having medical abortion before 14 weeks? gestation | OR 1.42 [0.31, 6.5] | 1 study · 228 participants | Low Downgraded: risk of bias, imprecision |
Induction to expulsion interval ‐ not reported Summary of findings table ‐ Therapeutic ibuprofen 800 mg vs prophylactic ibuprofen 800 mg women having medical abortion before 14 weeks? gestation | no estimate extracted | NR | No studies |
Unscheduled contact with care Summary of findings table ‐ Therapeutic ibuprofen 800 mg vs prophylactic ibuprofen 800 mg women having medical abortion before 14 weeks? gestation | OR 1.03 [0.6, 1.77] | 1 study · 228 participants | Low Downgraded: risk of bias, imprecision |
Patient satisfaction with analgesia ‐ not reported Summary of findings table ‐ Therapeutic ibuprofen 800 mg vs prophylactic ibuprofen 800 mg women having medical abortion before 14 weeks? gestation | no estimate extracted | NR | No studies |
Patient satisfaction with abortion care overall Summary of findings table ‐ Therapeutic ibuprofen 800 mg vs prophylactic ibuprofen 800 mg women having medical abortion before 14 weeks? gestation | OR 0.52 [0.09, 2.89] | 1 study · 228 participants | Low Downgraded: risk of bias, imprecision |