Pregabalin 300 mg or 600 mg vs placebo
mg pregabalin · adults with moderate or severe neuropathic pain
2 findings from 1 review
- no estimate extracted300 participantsGRADE not reported
- no estimate extracted600 participantsGRADE not reported
Findings
What do systematic reviews say?
127 questions · 132 findings · 13 reviews
No studies found 13 · 9.8%GRADE not reported 4 · 3%Very low 31 · 23.5%Low 33 · 25%Moderate 27 · 20.5%High 24 · 18.2%
Pregabalin vs placebo
50% or greater reduction in seizure frequency · people with drug‐resistant focal epilepsy
Pregabalin may leads to higher 50% or greater reduction in seizure frequency ‐ ITT analysis compared with placebo (low certainty).
3 findings from 1 review
- RR 1.95 [1.4, 2.72]9 studies · 2663 participantsLow
- RR 2.91 [1.92, 4.42]9 studies · 2663 participantsVery low
- RR 1.1 [0.92, 1.31]9 studies · 2663 participantsVery low
Pregabalin vs placebo
Adverse effects: headache · people with drug‐resistant focal epilepsy
It is very uncertain whether pregabalin changes adverse effect: headache compared with placebo (very low certainty).
1 finding from 1 review
- RR 0.65 [0.45, 0.94]6 studies · 1850 participantsVery low
Pregabalin vs placebo
Nausea · people with drug‐resistant focal epilepsy
Pregabalin showed no clear difference in adverse effect: nausea compared with placebo (low certainty).
1 finding from 1 review
- RR 1.2 [0.56, 2.58]4 studies · 1267 participantsLow
Pregabalin vs placebo
Somnolence · people with drug‐resistant focal epilepsy
Pregabalin may leads to higher adverse effect: somnolence compared with placebo (low certainty).
1 finding from 1 review
- RR 2.05 [1.49, 2.81]9 studies · 2663 participantsLow
Pregabalin vs placebo
Weight gain · people with drug‐resistant focal epilepsy
Pregabalin may leads to higher adverse effect: weight gain compared with placebo (low certainty).
1 finding from 1 review
- RR 4.35 [2.34, 8.11]8 studies · 2488 participantsLow
Pregabalin vs active comparators
50% or greater reduction in seizure frequency · people with drug‐resistant focal epilepsy
Pregabalin showed no clear difference in 50% or greater reduction in seizurefrequency compared with active comparators (low certainty).
3 findings from 1 review
- RR 1.03 [0.85, 1.25]3 studies · 1286 participantsLow
- RR 1.6 [1.17, 2.19]3 studies · 1286 participantsVery low
- RR 0.67 [0.62, 0.74]3 studies · 1286 participantsModerate
Pregabalin vs active comparators
Seizure freedom · people with drug‐resistant focal epilepsy
It is very uncertain whether pregabalin changes seizure freedom compared with active comparators (very low certainty).
1 finding from 1 review
- RR 0.59 [0.37, 0.95]2 studies · 802 participantsVery low
Pregabalin vs active comparators
Treatment withdrawal · people with drug‐resistant focal epilepsy
Pregabalin showed no clear difference in treatment withdrawal for any reason compared with active comparators (low certainty).
1 finding from 1 review
- RR 0.93 [0.76, 1.13]3 studies · 1286 participantsLow
Pregabalin vs active comparators
Withdrawals due to adverse events · people with drug‐resistant focal epilepsy
1 finding from 1 review
- 1.04 [0.73, 1.48]3 studies · 1286 participantsLow
Pregabalin vs active comparators
Ataxia · people with drug‐resistant focal epilepsy
1 finding from 1 review
- 1.72 [0.54, 5.55]1 study · 293 participantsLow
Pregabalin vs active comparators
Dizziness · people with drug‐resistant focal epilepsy
1 finding from 1 review
- 1.64 [0.85, 3.16]3 studies · 1286 participantsLow
Pregabalin vs active comparators
Adverse effect: fatigue · people with drug‐resistant focal epilepsy
1 finding from 1 review
- 1.72 [0.77, 3.83]1 study · 293 participantsLow
Pregabalin vs active comparators
Adverse effects: headache · people with drug‐resistant focal epilepsy
1 finding from 1 review
- 0.83 [0.41, 1.65]3 studies · 1286 participantsVery low
Pregabalin vs active comparators
Nausea · people with drug‐resistant focal epilepsy
1 finding from 1 review
- 0.2 [0.04, 1.01]1 study · 509 participantsVery low
Pregabalin vs active comparators
Somnolence · people with drug‐resistant focal epilepsy
1 finding from 1 review
- 1.16 [0.88, 1.53]3 studies · 1286 participantsLow
Pregabalin vs active comparators
Weight gain · people with drug‐resistant focal epilepsy
1 finding from 1 review
- 2.87 [0.94, 8.75]3 studies · 1286 participantsLow
Pregabalin vs placebo
Seizure freedom · people with drug‐resistant focal epilepsy
1 finding from 1 review
- 3.94 [1.5, 10.37]4 studies · 1125 participantsModerate
Pregabalin vs placebo
Treatment withdrawal · people with drug‐resistant focal epilepsy
Pregabalin probably leads to higher treatment withdrawal for any reason compared with placebo (moderate certainty).
1 finding from 1 review
- RR 1.33 [1.1, 1.6]9 studies · 2663 participantsModerate
Pregabalin vs placebo
Withdrawals due to adverse events · people with drug‐resistant focal epilepsy
Pregabalin probably leads to higher treatment withdrawal due to adverse effects compared with placebo (moderate certainty).
1 finding from 1 review
- RR 2.6 [1.86, 3.64]9 studies · 2663 participantsModerate