Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,310 questions · 1,358 findings · 214 reviews

No studies found 230 · 16.9%GRADE not reported 169 · 12.4%Very low 269 · 19.8%Low 277 · 20.4%Moderate 291 · 21.4%High 122 · 9%

SUMMARY OF FINDINGS FOR DECOMPRESSION vs medical treatment

Death or moderate disability (mRS > 3) at 6 to 12 months · malignant cerebral oedema after ischaemic stroke

Summary of findings table ‐ surgical decompression probably leads to lower death or moderate disability (mRS > 3) at 6 to 12 months compared with medical treatment alone (moderate certainty).

1 finding from 1 review

Medical or surgical intervention, or both, for gastro‐oesophageal reflux disease vs nil intervention, delayed intervention control, or placebo

Exacerbations: number of people experiencing moderate or severe exacerbations · treatment for asthma in adults and children with asthma and GORD

Medical or surgical intervention, or both, for gastro‐oesophageal… showed no clear difference in number of participants with moderate/severe acute exacerbations… compared with nil intervention, delayed intervention control, or placebo (low certainty).

1 finding from 1 review

Intervention not reported

MMRV randomised controlled trial ‐ moderate/severe cases ‐ 2 doses ‐ · children 9 months to 15 years old

The intervention leads to lower MMRV randomised controlled trial ‐ moderate/severe cases ‐ 2 doses ‐ (high certainty).

1 finding from 1 review

Intervention not reported

MMRV randomised controlled trial ‐ moderate/severe cases ‐ 2 doses ‐ · children 9 months to 15 years old

The intervention leads to lower MMRV randomised controlled trial ‐ moderate/severe cases ‐ 2 doses ‐ (high certainty).

1 finding from 1 review

Intervention not reported

MMRV randomised controlled trial ‐ moderate/severe cases ‐ 2 doses ‐ · children 9 months to 15 years old

The intervention leads to lower MMRV randomised controlled trial ‐ moderate/severe cases ‐ 2 doses ‐ (high certainty).

1 finding from 1 review

Intervention not reported

MMR+V randomised controlled trial ‐ moderate/severe cases ‐ 2 doses ‐ · children 9 months to 15 years old

The intervention leads to lower MMR+V randomised controlled trial ‐ moderate/severe cases ‐ 2 doses ‐ (high certainty).

1 finding from 1 review

Intervention not reported

MMR+V randomised controlled trial ‐ moderate/severe cases ‐ 2 doses ‐ · children 9 months to 15 years old

The intervention leads to lower MMR+V randomised controlled trial ‐ moderate/severe cases ‐ 2 doses ‐ (high certainty).

1 finding from 1 review

Intervention not reported

MMR+V randomised controlled trial ‐ moderate/severe cases ‐ 2 doses ‐ · children 9 months to 15 years old

The intervention leads to lower MMR+V randomised controlled trial ‐ moderate/severe cases ‐ 2 doses ‐ (high certainty).

1 finding from 1 review

Intervention not reported

Cohort studies ‐ autism risk (moderate/high), MMR · children 9 months to 15 years old

The intervention may leads to lower cohort studies ‐ autism risk (moderate/high), MMR (low certainty).

1 finding from 1 review

Monitoring ovarian stimulation by transvaginal ultrasound (TVUS) only vs monitoring with TVUS plus serum estradiol

OHSS · Women undergoing ovarian stimulation with gonadotrophins in IVF and ICSI procedures

Monitoring ovarian stimulation by transvaginal ultrasound (TVUS) only showed no clear difference in OHSS rate (mild, moderate or severe) per woman compared with monitoring with TVUS plus serum estradiol (low certainty).

1 finding from 1 review