Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

188 questions · 193 findings · 30 reviews · Schizophrenia

No studies found 54 · 28%GRADE not reported 23 · 11.9%Very low 50 · 25.9%Low 47 · 24.4%Moderate 15 · 7.8%High 4 · 2.1%

SULPIRIDE vs placebo

Global state: clinically significant response in global state ‐ by long term ‐ not measured · patients with schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

SULPIRIDE vs placebo

Quality of life: average score ‐ by long term ‐ not measured · patients with schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

BRIEF FAMILY INTERVENTION vs usual care

Hospital admissions · patients with schizophrenia

It is very uncertain whether BRIEF FAMILY INTERVENTION changes service utilisation ‐ hospital admission ‐ medium to long term… compared with STANDARD CARE (very low certainty).

1 finding from 1 review

BRIEF FAMILY INTERVENTION vs usual care

Global state: relapse ‐ medium term ‐ not measured · patients with schizophrenia

BRIEF FAMILY INTERVENTION showed no clear difference in global state ‐ relapse ‐ medium to long term relapse rates (clinical… compared with STANDARD CARE (low certainty).

1 finding from 1 review

ANY INTERMITTENT DRUG TECHNIQUE vs MAINTENANCE THERAPY

Relapse · patients with schizophrenia

ANY INTERMITTENT DRUG TECHNIQUE probably leads to higher relapse: long term (+ 26 weeks) as defined in each study compared with MAINTENANCE THERAPY (moderate certainty).

2 findings from 1 review

INTERMITTENT (EARLY‐BASED) vs MAINTENANCE THERAPY

Adverse effects: tardive dyskinesia: long term (+ 26 weeks) as defined in each study · patients with schizophrenia

INTERMITTENT (EARLY‐BASED) showed no clear difference in adverse effects: tardive dyskinesia: long term (+26 weeks) as… compared with MAINTENANCE THERAPY (low certainty).

1 finding from 1 review