ANY INTERMITTENT DRUG TECHNIQUE vs MAINTENANCE THERAPY: Relapse
ANY INTERMITTENT DRUG TECHNIQUE probably leads to higher relapse: long term (+ 26 weeks) as defined in each study compared with MAINTENANCE THERAPY (moderate certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
ANY INTERMITTENT DRUG TECHNIQUE vs MAINTENANCE THERAPY Relapse: long term (+ 26 weeks) as defined in each study · patients with schizophrenia ANY INTERMITTENT DRUG TECHNIQUE probably leads to higher relapse: long term (+ 26 weeks) as defined in each study compared with MAINTENANCE THERAPY (moderate certainty). Intermittent drug techniques for schizophrenia (2013) · Cochrane Headline outcomes only | RR 2.46 [1.7, 3.54] | 7 studies · 436 participants | Moderate |
INTERMITTENT (DRUG HOLIDAY) vs MAINTENANCE THERAPY Relapse: long term (+ 26 weeks) as defined in each study · patients with schizophrenia It is very uncertain whether INTERMITTENT (DRUG HOLIDAY) changes relapse: long term (+ 26 weeks) as defined in each study compared with MAINTENANCE THERAPY (very low certainty). Intermittent drug techniques for schizophrenia (2013) · Cochrane Headline outcomes only | RR 1.7 [0.54, 5.38] | 2 studies · 61 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Intermittent drug techniques for schizophrenia 2013 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.