Number of children with a caries increment · Children (permanent teeth; baseline 8 to 10 years)
Xylitol lozenges (4.7 g/day) showed no clear difference in number of children with a caries increment compared with no treatment; GRADE not reported.
1 finding from 1 review
Elevated mutans streptococci levels (>=4 with caries screen; high vs low) · Children and adolescents below 18 years at study start (included studies: children from birth to 15 years), with mixed, permanent or…
It is very uncertain whether chlorhexidine varnish (10%) changes elevated mutans streptococci levels (>=4 with caries screen; high vs… compared with placebo or no treatment (very low certainty).
1 finding from 1 review
CA VI activity · Children (age about 2-9 years) across the 7 meta-analyzed activity samples; excludes Kivela 1999 adults (18-24 years), qualitative only…
Salivary/biofilm CA VI activity is significantly higher in individuals with dental caries than in caries-free individuals (SMD 0.894, 95% CI 0.386 to 1.392; not GRADE-rated).
1 finding from 1 review
Dental caries · Children and adolescents (<18 years) living with HIV (CLWH)
Among HIV+ children, HAART versus no HAART showed no significant difference in the odds of dental caries by DMFT in cross-sectional studies (OR 1.29, 95% CI 0.59 to 2.84; ungraded).
2 findings from 1 review
Association between antiretroviral therapy and dental caries in children and adolescents with HIV: a systematic review… 2025 All outcomesNot specified (cross-sectional) · Dental examination of children/adolescents with HIV in clinic and community settings; low- and middle-income countries (Brazil, India, Nigeria, Cambodia, Uganda, West Africa) · Cross-sectional studies; DMFT index
OR 1.29 [0.59, 2.84]
Studies not reported
GRADE not reported
Association between antiretroviral therapy and dental caries in children and adolescents with HIV: a systematic review… 2025 All outcomesNot specified (cross-sectional) · Dental examination of children/adolescents with HIV in clinic and community settings; low- and middle-income countries (Brazil, India, Nigeria, Cambodia, Uganda, West Africa) · Cross-sectional studies; deft index
OR 1.09 [0.65, 1.82]
Studies not reported
GRADE not reported
Dental caries in permanent teeth · Children and adolescents (<18 years) living with HIV (CLWH)
Among HIV+ children, HAART was associated with a significantly higher DMFT index than no HAART in case-control studies (MD 2.02, 95% CI 1.24 to 2.80; ungraded).
1 finding from 1 review
Caries in primary teeth: dmft (3 years) · Children and adolescents (<18 years) living with HIV (CLWH)
Among HIV+ children, HAART versus no HAART showed no significant difference in the dmft index in case-control studies (MD 0.66, 95% CI -0.26 to 1.58; ungraded).
1 finding from 1 review
Intervention not reported
Dental caries prevalence in children
1 finding from 1 review
Intervention not reported
Dental caries in children
The intervention led to higher dental caries in children; GRADE not reported.
1 finding from 1 review
OR 1.20 [1.04, 1.36]
4 studies
GRADE not reported
Intervention not reported
Dental caries prevalence · Children (<12 years) and adolescents (12-18 years) with type 1 diabetes
Caries prevalence was highest in South American studies at 84% (95% CI 0.67 to 0.94); certainty not graded.
1 finding from 1 review
Intervention not reported
Dental caries prevalence · Children (<12 years) and adolescents (12-18 years) with type 1 diabetes
Caries prevalence in Asian studies was 67% (95% CI 0.43 to 0.85); certainty not graded.
1 finding from 1 review
Intervention not reported
Dental caries prevalence · Children (<12 years) and adolescents (12-18 years) with type 1 diabetes
Caries prevalence was lowest among those with good metabolic control at 47% (95% CI 0.30 to 0.64); certainty not graded.
1 finding from 1 review
Intervention not reported
Dental caries prevalence · Children (<12 years) and adolescents (12-18 years) with type 1 diabetes
Caries prevalence in European studies was 57% (95% CI 0.41 to 0.72); certainty not graded.
1 finding from 1 review
Intervention not reported
Dental caries prevalence · Children (<12 years) and adolescents (12-18 years) with type 1 diabetes
The pooled prevalence of dental caries among children and adolescents with type 1 diabetes was 67% (95% CI 0.56 to 0.77), with high heterogeneity (I2=83%); certainty not graded.
1 finding from 1 review
Dental caries prevalence · Children and adolescents with type 1 diabetes assessed with DMFT
When restricted to studies using DMFT, the pooled dental caries prevalence was 62%.
1 finding from 1 review
Prevalence 0.62
Studies not reported
GRADE not reported
Intervention not reported
Dental caries prevalence · Children (<12 years) and adolescents (12-18 years) with type 1 diabetes
Caries prevalence in the single North American study was 64% (95% CI 0.52 to 0.74); certainty not graded.
1 finding from 1 review
Intervention not reported
Dental caries prevalence · Children (<12 years) and adolescents (12-18 years) with type 1 diabetes
Caries prevalence was lower in those with mean age >10 years at 57% (95% CI 0.45 to 0.68); certainty not graded.
1 finding from 1 review
Intervention not reported
Dental caries prevalence · Children (<12 years) and adolescents (12-18 years) with type 1 diabetes
Caries prevalence was higher in those with mean age <=10 years at 80% (95% CI 0.74 to 0.85); certainty not graded.
1 finding from 1 review
Intervention not reported
Dental caries prevalence · Children (<12 years) and adolescents (12-18 years) with type 1 diabetes
Caries prevalence among those with poor metabolic control was 66% (95% CI 0.43 to 0.83); certainty not graded.
1 finding from 1 review
Oral health-related quality of life · Indians
In adolescents (10-19 years), dental caries was associated with poorer OHRQoL (pooled OR 3.92; 5 studies); ungraded.
5 findings from 1 review
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Oral health-related quality of life · Indian children aged 3-5 years
In children aged 3-5 years, early childhood caries was significantly associated with poorer OHRQoL (narrative; 3 studies); ungraded.
1 finding from 1 review