Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,368 questions · 1,413 findings · 89 reviews · Common Mental Disorders

No studies found 232 · 16.4%GRADE not reported 82 · 5.8%Very low 395 · 28%Low 331 · 23.4%Moderate 341 · 24.1%High 32 · 2.3%

Mindfulness‐based 'third wave' cognitive and behavioural therapies vs ALL OTHER PSYCHOLOGICAL THERAPIES

Clinical non‐remission at post‐treatment · patients with depression

It is very uncertain whether mindfulness‐based 'third wave' cognitive and behavioural therapies changes non‐remission at post‐treatment compared with other psychological therapies (very low certainty).

1 finding from 1 review

Agomelatine vs SNRIs

Drop out due to inefficacy Number of participants who dropped out due to inefficacy during the trial, as a proportion of the total number of randomised participants · patients with major depression

It is very uncertain whether agomelatine changes drop out due to inefficacy Number of participants who dropped out… compared with SNRI (very low certainty).

1 finding from 1 review

Agomelatine vs SNRIs

Adverse effects (drop‐outs due to adverse effects4) · patients with major depression

It is very uncertain whether agomelatine changes drop outs due to side effects Number of participants who dropped out… compared with SNRI (very low certainty).

1 finding from 1 review

Agomelatine vs SNRIs

Participants with at least some Side Effects · patients with major depression

It is very uncertain whether agomelatine changes total number of patients with side effects Total number of… compared with SNRI (very low certainty).

1 finding from 1 review

Agomelatine vs SSRI

Total drop outs Total number of participants who dropped out during the trial as a proportion of the total number of randomised participants · patients with major depression

It is very uncertain whether agomelatine changes total drop outs Total number of participants who dropped out during… compared with SSRI (very low certainty).

1 finding from 1 review

Agomelatine vs SSRI

Drop out due to inefficacy Number of participants who dropped out due to inefficacy during the trial, as a proportion of the total number of randomised participants · patients with major depression

It is very uncertain whether agomelatine changes drop out due to inefficacy Number of participants who dropped out… compared with SSRI (very low certainty).

1 finding from 1 review

Agomelatine vs SSRI

Adverse effects (drop‐outs due to adverse effects4) · patients with major depression

It is very uncertain whether agomelatine changes drop outs due to side effects Number of participants who dropped out… compared with SSRI (very low certainty).

1 finding from 1 review

Agomelatine vs SSRI

Participants with at least some Side Effects · patients with major depression

It is very uncertain whether agomelatine changes total number of participants with side effects Total number of… compared with SSRI (very low certainty).

1 finding from 1 review

Agomelatine vs SNRIs

Total drop outs Total number of participants who dropped out during the trial as a proportion of the total number of randomised participants · patients with major depression

It is very uncertain whether agomelatine changes total drop outs Total number of participants who dropped out during… compared with SNRI (very low certainty).

1 finding from 1 review

Amitriptyline vs placebo

Acceptability of treatment Drop‐out for any reason · adults with Major Depressive Disorder

It is very uncertain whether amitriptyline changes acceptability of treatment Drop‐out for any reason compared with placebo (very low certainty).

1 finding from 1 review